Emerging Clinical Activity of REGN1979, an Anti-CD20 x Anti-CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Follicular Lymphoma (FL), Diffuse Large B-Cell Lymphoma (DLBCL), and Other B-Cell Non-Hodgkin Lymphoma (B-NHL) Subtypes

被引:12
|
作者
Bannerji, Rajat [1 ]
Arnason, Jon E. [2 ]
Advani, Ranjana [3 ]
Brown, Jennifer R. [4 ]
Allan, John N. [5 ]
Ansell, Stephen M. [6 ]
Barnes, Jeffrey [7 ]
O'Brien, Susan M. [8 ]
Chavez, Julio C. [9 ]
Duell, Johannes [10 ]
Lowy, Israel [11 ]
Charnas, Robert [11 ]
Sternberg, David [11 ]
Ambati, Srikanth [11 ]
Adriaens, Lieve [12 ]
Ufkin, Melanie [11 ]
Yan, Xiaoyu [11 ]
Li, Jingjin [12 ]
Navarro, Mark [11 ]
Gasparini, Peter [11 ]
Jankovic, Vladimir [11 ]
Fiaschi, Nathalie [11 ]
Zhang, Wen [11 ]
Hamon, Sara [11 ]
Thurston, Gavin [11 ]
Topp, Max S. [10 ]
机构
[1] Canc Inst New Jersey, New Brunswick, NJ USA
[2] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
[3] Stanford Univ, Stanford, CA 94305 USA
[4] Dana Farber Canc Inst, Boston, MA 02115 USA
[5] Weill Cornell Med, Div Hematol & Oncol, New York, NY USA
[6] Mayo Clin, Div Hematol, Rochester, MN USA
[7] Massachusetts Gen Hosp, Boston, MA 02114 USA
[8] Univ Calif Irvine, Irvine, CA USA
[9] H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL USA
[10] Univ Hosp Wurzburg, Wurzburg, Germany
[11] Regeneron Pharmaceut Inc, Tarrytown, NY USA
[12] Regeneron Pharmaceut Inc, Basking Ridge, NJ USA
关键词
D O I
10.1182/blood-2018-99-113328
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1690
引用
收藏
页数:5
相关论文
共 50 条
  • [1] Clinical Activity of REGN1979, a Bispecific Human, Anti-CD20 x Anti-CD3 Antibody, in Patients with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (B-NHL)
    Bannerji, Rajat
    Allan, John N.
    Arnason, Jon E.
    Brown, Jennifer R.
    Advani, Ranjana H.
    Barnes, Jeffrey A.
    Ansell, Stephen M.
    O'Brien, Susan M.
    Chavez, Julio
    Duell, Johannes
    David, Kevin A.
    Martin, Peter
    Joyce, Robin M.
    Charnas, Robert
    Ambati, Srikanth R.
    Adriaens, Lieve
    Ufkin, Melanie
    Zhu, Min
    Li, Jingjin
    Gasparini, Peter
    Ibrahim, Anfal
    Jankovic, Vladimir
    Fiaschi, Nathalie
    Aina, Olulanu
    Zhang, Wen
    Deering, Raquel P.
    Hamon, Sara
    Thurston, Gavin
    Murphy, Andrew J.
    Weinreich, David M.
    Yancopoulos, George D.
    Lowy, Israel
    Sternberg, David
    Topp, Max S.
    BLOOD, 2019, 134
  • [2] A Phase 2 Study of REGN1979, an Anti-CD20 x Anti-CD3 Bispecific Antibody (Ab), in Patients with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (B-NHL)
    Topp, Max S.
    Duell, Johannes
    Li, Jingjin
    Jankovic, Vladimir
    Lowy, Israel
    Sternberg, David
    Adriaens, Lieve
    Peterman, Mary
    Ambati, Srikanth R.
    Bannerji, Rajat
    BLOOD, 2019, 134
  • [3] A Phase 2 Study of Odronextamab (REGN1979), a CD20 x CD3 Bispecific Antibody, in Patients with Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma
    Kim, Tae Min
    Alonso, Arancha
    Prince, Miles
    Taszner, Michal
    Cho, Seok-Goo
    Stevens, Don A.
    Poon, Michelle
    Lim, Francesca
    Le Gouill, Steven
    Carpio, Cecilia
    Keating, Mary-Margaret
    Adriaens, Lieve
    Ufkin, Melanie
    Sabir, Ayesha
    Li, Jingjin
    Jankovic, Vladimir
    Zhu, Min
    Brouwer-Visser, Jurriaan
    Leng, Siyang
    Sirulnik, L. Andres
    Chaudhry, Aafia
    Ambati, Srikanth R.
    Seog, Kim Won
    BLOOD, 2020, 136
  • [4] Anti-CD20–atezolizumab–polatuzumab vedotin in relapsed/refractory follicular and diffuse large B-cell lymphoma
    Max S. Topp
    Herbert Eradat
    Axel Florschütz
    Andreas Hochhaus
    Tomasz Wrobel
    Jan Walewski
    Wanda Knopinska-Posluszny
    Abraham S. Kanate
    Ewa Lech-Maranda
    Uta Brunnberg
    Surya Chitra
    Tina G. Nielsen
    Gila Sellam
    Mahesh Shivhare
    Izidore S. Lossos
    Journal of Cancer Research and Clinical Oncology, 2023, 149 : 811 - 817
  • [5] PHARMACOKINETICS AND EXPOSURE-RESPONSE FOR REGN1979, A BISPECIFIC ANTI-CD20 X ANTI-CD3 ANTIBODY, IN PATIENTS WITH NON-HODGKIN'S LYMPHOMA.
    Yang, F.
    Zhu, M.
    Toroghi, M.
    Putluri, D.
    Yan, H.
    Davis, J.
    DiCioccio, A.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2020, 107 : S120 - S120
  • [6] Polatuzumab vedotin, venetoclax, and an anti-CD20 monoclonal antibody in relapsed/refractory B-cell non-Hodgkin lymphoma
    Yuen, Sam
    Phillips, Tycel J.
    Bannerji, Rajat
    Marlton, Paula
    Gritti, Giuseppe
    Seymour, John F.
    Johnston, Anna
    Arthur, Christopher
    Dodero, Anna
    Sharma, Sunil
    Hirata, Jamie
    Musick, Lisa
    Flowers, Christopher R.
    AMERICAN JOURNAL OF HEMATOLOGY, 2024, 99 (07) : 1281 - 1289
  • [7] Safety and Preliminary Clinical Activity of REGN1979, an Anti-CD20 x Anti-CD3 Bispecific Antibody, in Patients with B-NHL Previously Treated with CD20-Directed Antibody Therapy
    Bannerji, Rajat
    Advani, Ranjana H.
    Brown, Jennifer R.
    Arnason, Jon E.
    Barnes, Jeffrey A.
    Allan, John N.
    Ansell, Stephen M.
    O'Brien, Susan M.
    Chavez, Julio C.
    Adriaens, Lieve
    Ufkin, Melanie
    Kostic, Ana
    Paccaly, Anne Josee
    Gao, Bo
    Lowy, Israel
    Sternberg, David
    Topp, Max S.
    BLOOD, 2017, 130
  • [8] Activity and safety of ibrutinib and durvalumab in patients with relapsed or refractory follicular lymphoma (FL) or diffuse large B-cell lymphoma (DLBCL)
    Herrera, A.
    Goy, A.
    Mehta, A.
    Ramchandren, R.
    Pagel, J.
    Svoboda, J.
    Guan, S.
    Hill, J.
    Kwei, K.
    Liu, E.
    Phillips, T.
    EUROPEAN JOURNAL OF CANCER, 2018, 103 : E17 - E18
  • [9] Efficient inhibition of human B-cell lymphoma xenografts with an anti-CD20 X anti-CD3 bispecific diabody
    Xiong, DS
    Xu, YF
    Liu, HZ
    Peng, H
    Shao, XF
    Lai, ZZ
    Fan, DM
    Yang, M
    Han, JL
    Xie, Y
    Yang, CZ
    Zhu, ZQ
    CANCER LETTERS, 2002, 177 (01) : 29 - 39
  • [10] Maintenance therapy using the anti-CD20 antibody Rituximab in patients with B-cell non-Hodgkin lymphoma
    Neumann, F
    Martin, S
    Kronenwett, R
    Fischer, C
    Kondakci, M
    Kobbe, G
    Gattermann, N
    Haas, R
    BLOOD, 2003, 102 (11) : 298B - 298B