Multi-tasking: nuclear transcription factors with novel roles in the mitochondria

被引：92

作者：

Szczepanek, Karol ^{[1
,2
,3
]}

Lesnefsky, Edward J. ^{[1
,2
,3
,4
]}

Larner, Andrew C. ^{[1
,2
]}

机构：

[1] Virginia Commonwealth Univ, Dept Biochem & Mol Biol, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Massey Canc Ctr, Richmond, VA 23298 USA

[3] Virginia Commonwealth Univ, Dept Internal Med, Div Cardiol, Pauley Heart Ctr, Richmond, VA 23298 USA

[4] McGuire Dept Vet Affairs Med Ctr, Med Serv, Richmond, VA 23249 USA

来源：

TRENDS IN CELL BIOLOGY | 2012年 / 22卷 / 08期

关键词：

nuclear transcription factors; mitochondrial function; apoptosis; STAT3; NF-KAPPA-B; ELEMENT-BINDING PROTEIN; INTERFERON REGULATORY FACTOR-3; ELECTRON-TRANSPORT CHAIN; SIGNAL TRANSDUCER; GENE-EXPRESSION; HEART-FAILURE; CYTOCHROME-C; CELL-GROWTH; P53;

D O I：

10.1016/j.tcb.2012.05.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Coordinated responses between the nucleus and mitochondria are essential for the maintenance of homeostasis. For over 15 years, pools of nuclear transcription factors (TFs), such as p53 and nuclear hormone receptors, have been observed in the mitochondria. The contribution of the mitochondrial pool of these TFs to their well-defined biological actions is in some cases clear and in others not well understood. Recently, a small mitochondrial pool of the TF signal transducer and activator of transcription factor 3 (STAT3) was shown to modulate the activity of the electron transport chain (ETC). The mitochondrial function of STAT3 encompasses both its biological actions in the heart as well as its oncogenic effects. This review highlights advances in our understanding of how mitochondrial pools of nuclear TFs may influence the function of this organelle.

引用

页码：429 / 437

页数：9