Multi-tasking: nuclear transcription factors with novel roles in the mitochondria

被引：92

作者：

Szczepanek, Karol ^{[1
,2
,3
]}

Lesnefsky, Edward J. ^{[1
,2
,3
,4
]}

Larner, Andrew C. ^{[1
,2
]}

机构：

[1] Virginia Commonwealth Univ, Dept Biochem & Mol Biol, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Massey Canc Ctr, Richmond, VA 23298 USA

[3] Virginia Commonwealth Univ, Dept Internal Med, Div Cardiol, Pauley Heart Ctr, Richmond, VA 23298 USA

[4] McGuire Dept Vet Affairs Med Ctr, Med Serv, Richmond, VA 23249 USA

来源：

TRENDS IN CELL BIOLOGY | 2012年 / 22卷 / 08期

关键词：

nuclear transcription factors; mitochondrial function; apoptosis; STAT3; NF-KAPPA-B; ELEMENT-BINDING PROTEIN; INTERFERON REGULATORY FACTOR-3; ELECTRON-TRANSPORT CHAIN; SIGNAL TRANSDUCER; GENE-EXPRESSION; HEART-FAILURE; CYTOCHROME-C; CELL-GROWTH; P53;

D O I：

10.1016/j.tcb.2012.05.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Coordinated responses between the nucleus and mitochondria are essential for the maintenance of homeostasis. For over 15 years, pools of nuclear transcription factors (TFs), such as p53 and nuclear hormone receptors, have been observed in the mitochondria. The contribution of the mitochondrial pool of these TFs to their well-defined biological actions is in some cases clear and in others not well understood. Recently, a small mitochondrial pool of the TF signal transducer and activator of transcription factor 3 (STAT3) was shown to modulate the activity of the electron transport chain (ETC). The mitochondrial function of STAT3 encompasses both its biological actions in the heart as well as its oncogenic effects. This review highlights advances in our understanding of how mitochondrial pools of nuclear TFs may influence the function of this organelle.

引用

页码：429 / 437

页数：9

共 71 条

[1] CREB and the CRTC co-activators: sensors for hormonal and metabolic signals [J].

Altarejos, Judith Y. ;

Montminy, Marc .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2011, 12 (03) :141-151

[2] Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins - Implications for mitochondrial redox regulation and antioxidant defense [J].

Beer, SM ;

Taylor, ER ;

Brown, SE ;

Dahm, CC ;

Costa, NJ ;

Runswick, MJ ;

Murphy, MP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (46) :47939-47951

[3] Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion [J].

Boengler, Kerstin ;

Hilfiker-Kleiner, Denise ;

Heusch, Gerd ;

Schulz, Rainer .

BASIC RESEARCH IN CARDIOLOGY, 2010, 105 (06) :771-785

[4]

Bogdanov MB, 1998, J NEUROCHEM, V71, P2642

[5] IκB-α, the NF-κB inhibitors subunit, interacts with ANT, the mitochondrial ATP/ADP translocator [J].

Bottero, V ;

Rossi, F ;

Samson, M ;

Mari, M ;

Hofman, P ;

Peyron, JF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (24) :21317-21324

[6] Cyclic AMP-responsive element binding protein in brain mitochondria [J].

Cammarota, M ;

Paratcha, G ;

Bevilaqua, LRM ;

de Stein, ML ;

Lopez, M ;

de Iraldi, AP ;

Izquierdo, I ;

Medina, JH .

JOURNAL OF NEUROCHEMISTRY, 1999, 72 (06) :2272-2277

[7] Viral apoptosis is induced by IRF-3-mediated activation of Bax [J].

Chattopadhyay, Saurabh ;

Marques, Joao T. ;

Yamashita, Michifumi ;

Peters, Kristi L. ;

Smith, Kevin ;

Desai, Avanti ;

Williams, Bryan R. G. ;

Sen, Ganes C. .

EMBO JOURNAL, 2010, 29 (10) :1762-1773

[8] Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis [J].

Chipuk, JE ;

Kuwana, T ;

Bouchier-Hayes, L ;

Droin, NM ;

Newmeyer, D ;

Schuler, M ;

Green, DR .

SCIENCE, 2004, 303 (5660) :1010-1014

[9] Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells [J].

Chueh, Fu-Yu ;

Leong, King-Fu ;

Yu, Chao-Lan .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 402 (04) :778-783

[10] NF-κB and IκBα are found in the mitochondria -: Evidence for regulation of mitochondrial gene expression by NF-κB [J].

Cogswell, PC ;

Kashatus, DF ;

Keifer, JA ;

Guttridge, DC ;

Reuther, JY ;

Bristow, C ;

Roy, S ;

Nicholson, DW ;

Baldwin, AS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (05) :2963-2968

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