A new synthesis of phenolic 1-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines

被引：0

作者：

Ikeuchi, M ^{[1
]}

Inoue, K ^{[1
]}

Yamamoto, S ^{[1
]}

Yamauchi, A ^{[1
]}

Kihara, M ^{[1
]}

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

来源：

HETEROCYCLES | 2005年 / 65卷 / 12期

关键词：

3-benzazepine; phenolic benzazepine; intramolecular Barbier reaction; cyclization; N-phenethylphenacylamine;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

7,8-Dihydroxy-1-phenyl- and 1-(3- and 4-hydroxyphenyl)-1-hydroxy-2,3,4,5-tetrahydro- 1H-3-benzazepine derivatives (2a,b) and (3a-c) were synthesized by intramolecular Barbier reaction of N-(2-iodophenethyl)phenacylamines (5a,b) and (12a-c) with n-C(4)H(9)Li as a key reaction step.

引用

页码：2925 / 2935

页数：11

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