Highly regioselective synthesis of 2,4,5-(hetero) aryl substituted oxazoles by intermolecular [3+2]-cycloaddition of unsymmetrical internal alkynes

被引：74
作者：
Chatzopoulou, Elli [1 ]
Davies, Paul W. [1 ]
机构：
[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 77期
关键词：
GOLD; CYCLOADDITION; NITRILES; 5-(3-INDOLYL)OXAZOLES; REARRANGEMENT; CATALYSIS; OXIDATION; MOIETIES; YLIDES; ACCESS;
D O I：
10.1039/c3cc45410j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A robust N-nucleophilic 1,3-N,O-dipole equivalent reacts with unsymmetrical internal alkynes under gold catalysis. Conjugation from a remote nitrogen lone pair enables and controls this convergent and highly regioselective process.
引用
收藏
页码：8617 / 8619
页数：3
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