Highly regioselective synthesis of 2,4,5-(hetero) aryl substituted oxazoles by intermolecular [3+2]-cycloaddition of unsymmetrical internal alkynes

被引：74

作者：

Chatzopoulou, Elli ^{[1
]}

Davies, Paul W. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 77期

关键词：

GOLD; CYCLOADDITION; NITRILES; 5-(3-INDOLYL)OXAZOLES; REARRANGEMENT; CATALYSIS; OXIDATION; MOIETIES; YLIDES; ACCESS;

D O I：

10.1039/c3cc45410j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A robust N-nucleophilic 1,3-N,O-dipole equivalent reacts with unsymmetrical internal alkynes under gold catalysis. Conjugation from a remote nitrogen lone pair enables and controls this convergent and highly regioselective process.

引用

页码：8617 / 8619

页数：3

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