T cells in atherosclerosis

被引：134

作者：

Tse, Kevin ^{[1
,2
]}

Tse, Harley ^{[3
]}

Sidney, John ^{[4
]}

Sette, Alex ^{[4
]}

Ley, Klaus ^{[2
]}

机构：

[1] Univ Calif San Diego, Med Ctr, Dept Internal Med, Div Rheumatol Allergy & Immunol, La Jolla, CA 92093 USA

[2] La Jolla Inst Allergy & Immunol, Div Inflammat Biol, La Jolla, CA 92037 USA

[3] Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USA

[4] La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA

来源：

INTERNATIONAL IMMUNOLOGY | 2013年 / 25卷 / 11期

基金：

美国国家卫生研究院;

关键词：

atherosclerosis; inflammation; T cell; LOW-DENSITY-LIPOPROTEIN; HEAT-SHOCK-PROTEIN; DENDRITIC CELLS; NKT CELLS; HUMAN HEAT-SHOCK-PROTEIN-60; PROINFLAMMATORY CYTOKINES; REDUCED ATHEROSCLEROSIS; MYOCARDIAL-INFARCTION; LESION DEVELOPMENT; IMMUNE-RESPONSES;

D O I：

10.1093/intimm/dxt043

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The contrasting and controversial roles of T-cell subsets in atherosclerosis.Atherosclerosis is a chronic inflammatory disease of the artery wall. Atherosclerotic lesions contain monocytes, macrophages, smooth muscle cells and T lymphocytes. Here, we review the role of T-lymphocyte subsets in atherosclerosis. Among CD4 T cells, T(h)1 cells are pro-atherogenic, T-reg cells are athero-protective and the role of T(h)2 and T(h)17 cells remains unclear. The role of follicular helper T cells in atherosclerosis remains unknown, as is the role of CD8 T cells. NKT cells bind glycolipid antigens and exert a pro-atherogenic role. The antigen specificity of T-cell responses in atherosclerosis is poorly understood. In order to enable antigen-specific prevention or therapy, a better understanding of these mechanisms is needed.

引用

页码：615 / 622

页数：8

共 100 条

[1] Immunization of low-density lipoprotein receptor deficient (LDL-RD) mice with heat shock protein 65 (HSP-65) promotes early atherosclerosis [J].

Afek, A ;

George, J ;

Gilburd, B ;

Rauova, L ;

Goldberg, I ;

Kopolovic, J ;

Harats, D ;

Shoenfeld, Y .

JOURNAL OF AUTOIMMUNITY, 2000, 14 (02) :115-121

[2] Natural regulatory T cells control the development of atherosclerosis in mice [J].

Ait-Oufella, H ;

Salomon, BL ;

Potteaux, S ;

Robertson, AKL ;

Gourdy, P ;

Zoll, J ;

Merval, R ;

Esposito, B ;

Cohen, JL ;

Fisson, S ;

Flavell, RA ;

Hansson, GK ;

Klatzmann, D ;

Tedgui, A ;

Mallat, Z .

NATURE MEDICINE, 2006, 12 (02) :178-180

[3] DEVELOPMENT OF HIGH POTENCY UNIVERSAL DR-RESTRICTED HELPER EPITOPES BY MODIFICATION OF HIGH-AFFINITY DR-BLOCKING PEPTIDES [J].

ALEXANDER, J ;

SIDNEY, J ;

SOUTHWOOD, S ;

RUPPERT, J ;

OSEROFF, C ;

MAEWAL, A ;

SNOKE, K ;

SERRA, HM ;

KUBO, RT ;

SETTE, A ;

GREY, HM .

IMMUNITY, 1994, 1 (09) :751-761

[4] Adaptive immunity and atherosclerosis [J].

Andersson, John ;

Libby, Peter ;

Hansson, Goran K. .

CLINICAL IMMUNOLOGY, 2010, 134 (01) :33-46

[5]

Barks JL, 1997, J IMMUNOL, V159, P4532

[6] Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements [J].

Barnden, MJ ;

Allison, J ;

Heath, WR ;

Carbone, FR .

IMMUNOLOGY AND CELL BIOLOGY, 1998, 76 (01) :34-40

[7] Human 60-kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaques [J].

Benagiano, M ;

D'Elios, MM ;

Amedei, A ;

Azzurri, A ;

van der Zee, R ;

Ciervo, A ;

Rombolà, G ;

Romagnani, S ;

Cassone, A ;

Del Prete, G .

JOURNAL OF IMMUNOLOGY, 2005, 174 (10) :6509-6517

[8]

Binder CJ, 2008, CURR DRUG TARGETS, V9, P190

[9] IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis [J].

Binder, CJ ;

Hartvigsen, K ;

Chang, MK ;

Miller, M ;

Broide, D ;

Palinski, W ;

Curtiss, LK ;

Corr, M ;

Witztum, JL .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (03) :427-437

[10] Co-accumulation of dendritic cells and natural killer T cells within rupture-prone regions in human atherosclerotic plaques [J].

Bobryshev, YV ;

Lord, RSA .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2005, 53 (06) :781-785

← 1 2 3 4 5 6 7 8 9 10 →