Serum 25-hydroxyvitamin D and IgE - a significant but nonlinear relationship

被引:191
作者
Hyppoenen, E. [1 ]
Berry, D. J. [1 ]
Wjst, M. [2 ]
Power, C. [1 ]
机构
[1] UCL Inst Child Hlth, MRC Ctr Epidemiol Child Hlth, London WC1N 1EH, England
[2] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Munich, Germany
基金
英国医学研究理事会;
关键词
25-hydroxyvitamin D; CYP27B1; IgE; vitamin D; BRITISH BIRTH COHORT; VITAMIN-D STATUS; AGE; 45; YEARS; PARATHYROID-HORMONE; D SUPPLEMENTATION; EARLY-CHILDHOOD; D METABOLISM; RISK; ASTHMA; ASSOCIATION;
D O I
10.1111/j.1398-9995.2008.01865.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Hormonal vitamin D system affects the determination of T-cell responses. It is unknown if there is an association between vitamin D status and allergic conditions. Our aim was to investigate differences in serum IgE concentrations by vitamin D status [measured by 25(OH)D] and by a genetic variation in a key vitamin D activation enzyme (CYP27B1) previously shown to be associated with type 1 diabetes. 9377 participants in the 1958 British birth cohort completed a biomedical assessment at 45 years of age ; 7288 eligible participants had data on 25(OH)D and IgE, with 6429 having further information on CYP27B1 genotype (-1260C > A). There was a nonlinear association between 25(OH)D and IgE (P-value for curvature = 0.0001). Compared with the reference group with the lowest IgE concentrations [25(OH)D 100-125 nmol/l], IgE concentrations were 29% higher (95% CI 9-48%) for participants with the 25(OH)D < 25 nmol/l, and 56% higher (95% CI 17-95%) for participants with 25(OH)D > 135 nmol/l (adjusted for sex, month, smoking, alcohol consumption, time spent outside, geographical location, social class, PC/TV time, physical activity, body mass index and waist circumference). CYP27B1 genotype was associated with both 25(OH)D (difference for A vs. C allele: 1.88%, 95% CI 0.37-3.4%, P = 0.01) and IgE concentrations (-6.59%, -11.6% to -1.42%, P = 0.01). These data suggest that there may be a threshold effect with both low and high 25(OH)D levels associated with elevated IgE concentrations. The same CYP27B1 allele that is protective of diabetes was associated with increased IgE concentrations.
引用
收藏
页码:613 / 620
页数:8
相关论文
共 50 条
  • [21] Impact of serum 25-hydroxyvitamin D on cardiac prognosis in Chinese patients with heart failure
    Hou, Ya-Min
    Zhao, Jian-Ye
    Liu, Hong-Yan
    BRITISH JOURNAL OF NUTRITION, 2019, 122 (02) : 162 - 171
  • [22] Serum 25-Hydroxyvitamin D, Parathyroid Hormone, and Mortality in Older Men
    Cawthon, Peggy M.
    Parimi, Neeta
    Barrett-Connor, Elizabeth
    Laughlin, Gail A.
    Ensrud, Kristine E.
    Hoffman, Andrew R.
    Shikany, James M.
    Cauley, Jane A.
    Lane, Nancy E.
    Bauer, Douglas C.
    Orwoll, Eric S.
    Cummings, Steven R.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (10) : 4625 - 4634
  • [23] Serum 25-Hydroxyvitamin D and Prevention of Breast Cancer: Pooled Analysis
    Mohr, Sharif B.
    Gorham, Edward D.
    Alcaraz, John E.
    Kane, Christopher J.
    Macera, Caroline A.
    Parsons, J. Kellogg
    Wingard, Deborah L.
    Garland, Cedric F.
    ANTICANCER RESEARCH, 2011, 31 (09) : 2939 - 2948
  • [24] Serum 25-hydroxyvitamin D (25-OH-D) in obese adolescents
    Garanty-Bogacka, Barbara
    Syrenicz, Malgorzata
    Goral, Joanna
    Krupa, Beata
    Syrenicz, Justyna
    Walczak, Mieczyslaw
    Syrenicz, Anhelli
    ENDOKRYNOLOGIA POLSKA, 2011, 62 (06) : 506 - 511
  • [25] Serum 25-hydroxyvitamin D concentration in Japanese Akita dogs: A survey
    Casini, L.
    Zago, D.
    Cavicchioli, E.
    Tomiazzo, C.
    VETERINARY AND ANIMAL SCIENCE, 2020, 10
  • [26] The relationship of serum 25-hydroxyvitamin D concentration with clinical variables in patients with oropharyngeal dysphagia
    Barni, Gabriela Cristofoli
    Moreira, Emilia Addison Machado
    da Silva, Alice Freitas
    Pereira Panza, Vilma Simoes
    Oliveira, Diane de Lima
    Moreno, Yara Maria Franco
    Furkim, Ana Maria
    CLINICAL NUTRITION ESPEN, 2020, 38 : 229 - 235
  • [27] The Effect of Obesity on the Relationship Between Serum Parathyroid Hormone and 25-Hydroxyvitamin D in Women
    Shapses, Sue A.
    Lee, Esther J.
    Sukumar, Deeptha
    Durazo-Arvizu, Ramon
    Schneider, Stephen H.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (05) : E886 - E890
  • [28] Serum 25-hydroxyvitamin D in erythropoietic protoporphyria
    Holme, S. A.
    Anstey, A. V.
    Badminton, M. N.
    Elder, G. H.
    BRITISH JOURNAL OF DERMATOLOGY, 2008, 159 (01) : 211 - 213
  • [29] The relationship between low maternal serum 25-hydroxyvitamin D levels and gestational diabetes mellitus according to the severity of 25-hydroxyvitamin D deficiency
    Zuhur, Sayid Shafi
    Erol, Rumeysa Selvinaz
    Kuzu, Idris
    Altuntas, Yuksel
    CLINICS, 2013, 68 (05) : 658 - 664
  • [30] Relationships of serum 25-hydroxyvitamin D, ionized calcium and parathyroid hormone after obesity surgery
    Hewitt, Stephen
    Aasheim, Erlend Tuseth
    Sovik, Torgeir Thorson
    Jahnsen, Jorgen
    Kristinsson, Jon
    Eriksen, Erik Fink
    Mala, Tom
    CLINICAL ENDOCRINOLOGY, 2018, 88 (03) : 372 - 379