Preparation of Bioactive Mesoporous Calcium Phosphate Granules

被引：15
|
作者：
Musskaya, O. N. [1 ]
Kulak, A. I. [1 ]
Krut'ko, V. K. [1 ]
Lesnikovich, Yu. A. [2 ]
Kazbanov, V. V. [3 ]
Zhitkova, N. S. [3 ]
机构：
[1] Belarusian Acad Sci, Inst Gen & Inorgan Chem, Ul Surganova 9-1, Minsk 220072, BELARUS
[2] Belarusian State Univ, Leningradskaya Ul 14, Minsk 220030, BELARUS
[3] Republican Sci & Pract Ctr Pediat Surg, Pr Nezavisimosti 64, Minsk 220013, BELARUS
来源：
INORGANIC MATERIALS | 2018年 / 54卷 / 02期
关键词：
calcium phosphates; hydroxyapatite; tricalcium phosphate; specific surface area; bioactivity; FIBRIN;
D O I：
10.1134/S0020168518020115
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Mesoporous calcium phosphate granules ranging in mesopore size from 11 to 19 nm have been prepared using cryogenic processing (-18A degrees C) of gels and extrusion of calcium phosphate paste. The granules based on acid calcium phosphates have a relatively small specific surface area (45 m(2)/g) in comparison with the neutral and basic calcium phosphates (84-155 m(2)/g). Preclinical in vivo trials on rats show that the presence of calcium phosphate granules in a bone defect considerably accelerates reparative osteogenesis in comparison with a control group of animals.
引用
收藏
页码：117 / 124
页数：8
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