Epigenetic regulation of drug metabolism and transport

被引：52

作者：

Peng, Lai ^{[1
,2
]}

Zhong, Xiaobo ^{[1
]}

机构：

[1] Univ Connecticut, Sch Pharm, Dept Pharmaceut Sci, Storrs, CT 06269 USA

[2] Shanghai Jiao Tong Univ, Key Lab Syst Biomed, Ctr Comparat Biomed, Inst Syst Biomed, Shanghai 200240, Peoples R China

来源：

ACTA PHARMACEUTICA SINICA B | 2015年 / 5卷 / 02期

关键词：

Drug metabolism; Dna methylation; Epigenetics; Histone modification; Non-coding RNA; Transporter; EMBRYONIC STEM-CELLS; SMALL HETERODIMER PARTNER; HUMAN PROSTATE-CANCER; DNA METHYLATION; HISTONE METHYLATION; GENE-EXPRESSION; HUMAN GENOME; DEVELOPMENTAL REGULATORS; NONCODING RNAS; VALPROIC ACID;

D O I：

10.1016/j.apsb.2015.01.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The drug metabolism is a biochemical process on modification of pharmaceutical substances through specialized enzymatic systems. Changes in the expression of drug-metabolizing enzyme genes can affect drug metabolism. Recently, epigenetic regulation of drug-metabolizing enzyme genes has emerged as an important mechanism Epigenetic regulation refers to heritable factors of genomic modifications that do not involve changes in DNA sequence. Examples of such modifications include DNA methylation, histone modifications, and non-coding RNAs. This review examines the widespread effect of epigenetic regulations on genes involved in drug metabolism, and also suggests a network perspective of epigenetic regulation. The epigenetic mechanisms have important clinical implications and may provide insights into effective drug development and improve, safety of drug therapy. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：106 / 112

页数：7

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