STMN1 overexpression correlates with biological behavior in human cutaneous squamous cell carcinoma

被引：16
|
作者：
Li, Xingyu [1 ]
Wang, Lulu [2 ]
Li, Tiejun [1 ,3 ]
You, Bo [4 ]
Shan, Yin [4 ]
Shi, Si [4 ]
Qian, Li [5 ]
Cao, Xiaolei [1 ]
机构：
[1] Nantong Univ, Dept Pathol Anat, Sch Med, Nantong 226001, Jiangsu, Peoples R China
[2] Nantong Municipal Ctr Dis Control & Prevent, Nantong 226001, Jiangsu, Peoples R China
[3] Nantong Univ, Small RNA Technol & Applicat Inst, Nantong 226016, Jiangsu, Peoples R China
[4] Nantong Univ, Sch Med, Nantong 226001, Jiangsu, Peoples R China
[5] Nantong Univ, Affiliated Hosp, Dept Oncol, Nantong 226001, Jiangsu, Peoples R China
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2015年 / 211卷 / 11期
基金：
中国博士后科学基金;
关键词：
Stathmin 1 (STMN1); Cutaneous squamous cell carcinoma (cSCC); siRNA; A431; STATHMIN; 1; TUMOR-CELLS; EXPRESSION; MARKER; METASTASIS; PROLIFERATION; PROGRESSION; PHENOTYPE; MIGRATION; CANCER;
D O I：
10.1016/j.prp.2015.07.009
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Stathmin I (STMNI) is an important molecule in regulating cellular microtubule dynamics and promoting microtubule depolymerization in interphase and late mitosis. Evidences showed that STMN1 was up-regulated in many cancers, but there was no report about the roles of STMNI in human cutaneous squamous cell carcinoma (cSCC). Here, we confirmed significant upregulation of STMN1 in cSCC tissues and cell lines compared with non-tumor counterparts. STMN1 upregulation was associated with the proliferation, migration, invasion and apoptosis of cSCC cells. The results suggested that STMNI may play an important role in the development and tumor progression of cSCC. (C) 2015 Elsevier GmbH. All rights reserved.
引用
收藏
页码：816 / 823
页数：8
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