Lipase-mediated kinetic resolution of racemic and desymmetrization of prochiral organophosphorus P-boranes

被引：15

作者：

Kielbasinski, P ^{[1
]}

Albrycht, M ^{[1
]}

Zurawinski, R ^{[1
]}

Mikolajczyk, M ^{[1
]}

机构：

[1] Polish Acad Sci, Ctr Mol & Macromol Studies, Dept Heteororg Chem, PL-90363 Lodz, Poland

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2006年 / 39卷 / 1-4期

关键词：

lipase; kinetic resolution; desymmetrization; phosphine P-boranes; chirality;

D O I：

10.1016/j.molcatb.2006.01.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Enantiomerically enriched alkoxy(hydroxymethyl)phenylphosphine boranes were obtained via a lipase-catalyzed acetylation performed under kinetic resolution conditions. The reaction was slow and proceeded with a rather low enantioselectivity. A lipase-catalyzed acetylation of prochiral bis(2-hydroxyethyl)phenylphosphine borane resulted in its desymmetrization and gave the enantiomerically enriched monoacetyl derivative with ee up to 90%. (c) 2006 Elsevier B.V. All rghts reserved.

引用

页码：45 / 49

页数：5

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