Prognostic Role of MicroRNA-181a/b in Hematological Malignancies: A Meta-Analysis

被引:69
作者
Lin, Shenglong [1 ]
Pan, Lili [1 ]
Guo, Shicheng [2 ,3 ]
Wu, Junjie [2 ,3 ,4 ]
Jin, Li [2 ,3 ]
Wang, Jiu-Cun [2 ,3 ]
Wang, Shaoyuan [1 ]
机构
[1] Fujian Med Univ, Union Hosp, Dept Hematol, Fuzhou, Fujian Province, Peoples R China
[2] Fudan Univ, Natl Minist Educ, Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China
[3] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China
[4] Second Mil Med Univ, Changhai Hosp Shanghai, Dept Pneumol, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
ACUTE MYELOID-LEUKEMIA; DOWN-REGULATION; CELL-DIFFERENTIATION; BREAST-CANCER; EXPRESSION; MIR-181A; GENES; RNA; HSA-MIR-181B; RESISTANCE;
D O I
10.1371/journal.pone.0059532
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Emerging evidence has shown that miRNAs participate in human carcinogenesis as tumor suppressors or oncogenes, and have prognostic value for patients with cancers. In recent years, the miR-181 family was found dysregulated in a variety of human cancers and significantly associated with clinical outcome of cancerous patients. MiR-181a and miR-181b (miR-181a/b) were the most investigated members in the family. However, the results of miR-181a/b from different studies were inconsistent. Therefore, we performed a meta-analysis to summarize all the results from available studies, aiming to delineate the prognostic role of miR-181a/b in human cancers. Methods: The identified articles were retrieved from the two main on-line databases, PubMed and EMBASE. We extracted and estimated the hazard ratios (HRs) for overall survival (OS), which compared the high and low expression levels of miR-181a/b in patients of the available studies. Each individual HR was used to calculate the pooled HR. Results: Eleven studies of 1252 patients were selected into the final meta-analysis after a strict filtering and qualifying process. Fixed model or random model method was chosen depending on the heterogeneity between the studies. The subgroup analysis showed that high expressed miR-181a/b could prolong OS in patients with hematological malignancies rather than low expression level (HR = 0.717, P<0.0001). But the expression of miR-181a/b was not significantly relative to OS in patients with various cancers (HR = 0.861, p = 0.356). Conclusion: Our study indicates that the expression level of miR-181a/b is significantly associated with OS in hematological malignancies and can be an important clinical prognostic factor for those patients.
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页数:8
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