To Be Immunogenic, or Not to Be: That's the iPSC Question

被引：60

作者：

Kaneko, Shin ^{[1
]}

Yamanaka, Shinya ^{[1
,2
]}

机构：

[1] Kyoto Univ, Ctr IPS Cell Res & Applicat, Kyoto 6068507, Japan

[2] Gladstone Inst, San Francisco, CA 94158 USA

来源：

CELL STEM CELL | 2013年 / 12卷 / 04期

关键词：

PLURIPOTENT STEM-CELLS; INTEGRATION;

D O I：

10.1016/j.stem.2013.03.008

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The unexpected finding that autologous induced pluripotent stem cell (iPSC)-derived teratomas are immunogenic in syngeneic hosts sparked pessimism over their therapeutic potential; however, two recent reports (Guha et al., 2013 and Araki et al., 2013; the latter in this issue of Cell Stem Cell) contradict previous findings, showing no immunogenicity of in vitro differentiated syngeneic iPS-derived cells and supporting their safety.

引用

页码：385 / 386

页数：2

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