Somatosensory Evoked Potentials and Central Motor Conduction Times in children with dystonia and their correlation with outcomes from Deep Brain Stimulation of the Globus pallidus internus

被引：25

作者：

McClelland, Verity M. ^{[1
,2
]}

Fialho, Doreen ^{[3
]}

Flexney-Briscoe, Denise ^{[3
]}

Holder, Graham E. ^{[3
,4
,5
]}

Elze, Markus C. ^{[6
]}

Gimeno, Hortensia ^{[2
,7
]}

Siddiqui, Ata ^{[8
,9
]}

Mills, Kerry ^{[1
]}

Selway, Richard ^{[10
]}

Lin, Jean-Pierre ^{[2
]}

机构：

[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Basic & Clin Neurosci, Maurice Wohl Clin Neurosci Inst, London SE5 9RX, England

[2] Guys & St Thomas NHS Fdn Trust, Evelina Childrens Hosp, Childrens Neurosci Dept, Complex Motor Disorder Serv, London SE1 7EH, England

[3] Kings Coll Hosp NHS Fdn Trust, Dept Clin Neurophysiol, Denmark Hill, London SE5 9RS, England

[4] Moorfields Eye Hosp NHS Fdn Trust, 162 City Rd, London EC1V 2PD, England

[5] UCL, Inst Ophthalmol, 11-43 Bath St, London EC1V 9EL, England

[6] F Hoffmann La Roche & Cie AG, Biostat, CH-4070 Basel, Switzerland

[7] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol, London, England

[8] Guys & St Thomas NHS Fdn Trust, Dept Radiol, London, England

[9] Kings Coll Hosp NHS Fdn Trust, Dept Neuroradiol, London, England

[10] Kings Coll Hosp NHS Fdn Trust, Dept Funct Neurosurg, Denmark Hill, London SE5 9RS, England

来源：

CLINICAL NEUROPHYSIOLOGY | 2018年 / 129卷 / 02期

基金：

英国医学研究理事会;

关键词：

Dystonia; Secondary; Deep Brain Stimulation; Central Motor Conduction Time; Somatosensory Evoked Potentials; Dystonic cerebral palsy; Children; FAHN-MARSDEN DYSTONIA; CEREBRAL-PALSY; SECONDARY DYSTONIA; SENSORIMOTOR INTEGRATION; CORTEX; NEUROPHYSIOLOGY; CLASSIFICATION; ABNORMALITIES; EXCITABILITY; PLASTICITY;

D O I：

10.1016/j.clinph.2017.11.017

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives: To report Somatosensory Evoked Potentials (SEPs) and Central Motor Conduction Times (CMCT) in children with dystonia and to test the hypothesis that these parameters predict outcome from Deep Brain Stimulation (DBS). Methods: 180 children with dystonia underwent assessment for Globus pallidus internus (GPi) DBS, mean age 10 years (range 2.5-19). CMCT to each limb was calculated using Transcranial Magnetic Stimulation. Median and posterior tibial nerve SEPs were recorded over contralateral and midline centro-parietal scalp. Structural abnormalities were assessed with cranial MRI. One-year outcome from DBS was assessed as percentage improvement in Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS-m). Results: Abnormal CMCTs and SEPs were found in 19% and 47% of children respectively and were observed more frequently in secondary than primary dystonia. Of children proceeding to DBS, better outcome was seen in those with normal (n = 78/89) versus abnormal CMCT (n = 11/89) (p = 0.002) and those with normal (n = 35/51) versus abnormal SEPs (n = 16/51) (p = 0.001). These relationships were independent of dystonia aetiology and cranial MRI findings. Conclusions: CMCTs and SEPs provide objective evidence of motor and sensory pathway dysfunction in children with dystonia and relate to DBS outcome. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd.

引用

页码：473 / 486

页数：14

共 71 条

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