Cytotoxic abietane diterpenoids from Salvia leriifolia Benth

被引：5

作者：

Sarhadi, Elham ^{[1
]}

Ebrahimi, Samad Nejad ^{[2
]}

Hadjiakhoondi, Abbas ^{[1
,3
]}

Abbas-Mohammadi, Mahdi ^{[4
]}

Manayi, Azadeh ^{[1
]}

Parisi, Valentina ^{[5
]}

Pessolano, Emanuela ^{[5
]}

Petrella, Antonello ^{[5
]}

De Tommasi, Nunziatina ^{[5
]}

机构：

[1] Univ Tehran Med Sci, Med Plants Res Centr, Fac Pharm, Tehran, Iran

[2] Shahid Beheshti Univ, Dept Phytochem, Med Plants & Drugs Res Inst, Tehran, Iran

[3] Univ Tehran Med Sci, Dept Pharmacognosy, Fac Pharm, Tehran, Iran

[4] Univ Kashan, Dept Organ Chem, Fac Chem, Kashan, Iran

[5] Univ Salerno, Dipartimento Farm, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy

来源：

PHYTOCHEMISTRY | 2022年 / 202卷

关键词：

Salvia leriifolia; Lamiaceae; Diterpenoids; NMR; AGS cell; Phytochemical; LABDANE DITERPENOIDS; EXTRACTS; CONSTITUENTS; ANTIOXIDANT; TAXOQUINONE; SAHENDICA; GROWTH; ROOTS; ASSAY; BARK;

D O I：

10.1016/j.phytochem.2022.113310

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Phytochemical profiling of the root extract of Salvia leriifolia, an endemic plant of Iran, was investigated and 16 abietane diterpenes were isolated, and three were original compounds. 1D and 2D NMR and HRMS performed structural elucidation. The absolute configuration of the previously unreported compounds was determined by circular dichroism (ECD). The cytotoxicity of the isolated compounds was investigated against AGS, MIA PaCa-2, HeLa, and MCF-7 cell lines by the MTT assay. The known diterpene pisiferal possesses high cytotoxicity against all investigated cell lines at a concentration between 9.3 +/- 0.6 and 14.38 +/- 1.4 mu M.

引用

页数：7

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