The p90 RSK Family Members: Common Functions and Isoform Specificity

被引：99
作者：
Lara, Romain [1 ]
Seckl, Michael J. [1 ]
Pardo, Olivier E. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Div Oncol, London W12 0NN, England
来源：
CANCER RESEARCH | 2013年 / 73卷 / 17期
关键词：
RIBOSOMAL S6 KINASE; ACTIVATED PROTEIN-KINASE; CONSTITUTIVE ACTIVATION; SIGNALING PATHWAY; MAP KINASE; PHOSPHORYLATION; TRANSCRIPTION; INHIBITOR; IDENTIFICATION; DEGRADATION;
D O I：
10.1158/0008-5472.CAN-12-4448
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The p90 ribosomal S6 kinases (RSK) are implicated in various cellular processes, including cell proliferation, survival, migration, and invasion. In cancer, RSKs modulate cell transformation, tumorigenesis, and metastasis. Indeed, changes in the expression of RSK isoforms have been reported in several malignancies, including breast, prostate, and lung cancers. Four RSK isoforms have been identified in humans on the basis of their high degree of sequence homology. Although this similarity suggests some functional redundancy between these proteins, an increasing body of evidence supports the existence of isoform-based specificity among RSKs in mediating particular cellular processes. This review briefly presents the similarities between RSK family members before focusing on the specific function of each of the isoforms and their involvement in cancer progression. Cancer Res; 73(17); 5301-8. (C) 2013 AACR.
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收藏
页码：5301 / 5308
页数：8
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