In Vitro Susceptibility Testing of Bedaquiline against Mycobacterium avium Complex

被引：43

作者：

Brown-Elliott, Barbara A. ^{[1
]}

Philley, Julie V. ^{[2
]}

Griffith, David E. ^{[2
]}

Thakkar, Foram ^{[2
]}

Wallace, Richard J., Jr. ^{[1
,2
]}

机构：

[1] Univ Texas Hlth Sci Ctr Tyler, Mycobacteria Nocardia Res Lab, Dept Microbiol, Tyler, TX 75708 USA

[2] Univ Texas Hlth Sci Ctr Tyler, Dept Med, Tyler, TX USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 02期

关键词：

Mycobacterium avium complex; bedaquiline; nontuberculous mycobacteria; susceptibility testing; MULTIDRUG-RESISTANT TUBERCULOSIS; ATP SYNTHASE; DIARYLQUINOLINE TMC207; CROSS-RESISTANCE; LUNG-DISEASE; DRUG; RIFAPENTINE; CLOFAZIMINE; THERAPY;

D O I：

10.1128/AAC.01798-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We performed bedaquiline broth microdilution susceptibility testing using Clinical and Laboratory Standards Institute (CLSI) guidelines on 103 respiratory isolates of Mycobacterium avium complex (MAC), including multidrug-resistant isolates. Approximately 90% of isolates had bedaquiline MICs of <= 0.008 mu g/ml, and 102/103 isolates had MICs of <= 0.015 mu g/ml. Bedaquiline has excellent potential for use in patients with MAC infections, although for reasons of its metabolism by the cytochrome P450 system, it should not be given with rifampin.

引用

页数：4

共 50 条

[21] Antimicrobial Effect of Oxazolidinones and Its Synergistic Effect with Bedaquiline Against Mycobacterium abscessus Complex
Gao, Tianhui
Yao, Cong
Shang, Yuanyuan
Su, Renchun
Zhang, Xuxia
Ren, Weicong
Li, Shanshan
Shu, Wei
Pang, Yu
Li, Qi
INFECTION AND DRUG RESISTANCE, 2023, 16 : 279 - 287
[22] Verapamil Improves the Activity of Bedaquiline against Mycobacterium abscessus In Vitro and in Macrophages
Viljoen, Albertus
Raynaud, Clement
Johansen, Matt D.
Roquet-Baneres, Francoise
Herrmann, Jean-Louis
Daher, Wassim
Kremer, Laurent
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2019, 63 (09)
[23] Mutations associated with in vitro resistance to bedaquiline in Mycobacterium tuberculosis isolates in Australia
Martinez, Elena
Hennessy, Daneeta
Jelfs, Peter
Crighton, Taryn
Chen, Sharon C-A
Sintchenko, Vitali
TUBERCULOSIS, 2018, 111 : 31 - 34
[24] Mycobacterium avium Complex: Addressing Gaps in Diagnosis and Management
Daley, Charles L.
Winthrop, Kevin L.
JOURNAL OF INFECTIOUS DISEASES, 2020, 222 : S199 - S211
[25] The In vitro activity of carbapenems alone and in combination with β-lactamase inhibitors against difficult-to-treat mycobacteria; Mycobacterium tuberculosis, Mycobacterium abscessus, and Mycobacterium avium complex: A systematic review
Andersson, Viktoria
Froberg, Gabrielle
Dahl, Victor
Chryssanthou, Erja
Giske, Christian
Schon, Thomas
Forsman, Lina
INTERNATIONAL JOURNAL OF MYCOBACTERIOLOGY, 2023, 12 (03) : 211 - 225
[26] Treatment of Mycobacterium avium Complex (MAC)
Griffith, David E.
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 39 (03) : 351 - 361
[27] Relapse versus Reinfection of Mycobacterium avium Complex Pulmonary Disease Patient Characteristics and Macrolide Susceptibility
Boyle, Daniel P.
Zembower, Teresa R.
Qi, Chao
ANNALS OF THE AMERICAN THORACIC SOCIETY, 2016, 13 (11) : 1956 - 1961
[28] IN-VITRO AND IN-VIVO ACTIVITIES OF CLARITHROMYCIN AGAINST THE MYCOBACTERIUM-AVIUM COMPLEX
SAITO, H
TOMIOKA, H
SATO, K
DEKIO, S
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 1994, 4 (03) : 175 - 181
[29] Validation of bedaquiline drug-susceptibility testing by BACTEC MGIT 960 system for Mycobacterium tuberculosis
Sivaramakrishnan, Gomathi
Subramanyam, Balaji
Kumar, Michel Prem
Golla, Radhika
Tripathy, Srikanth Prasad
Mondal, Rajesh
INTERNATIONAL JOURNAL OF MYCOBACTERIOLOGY, 2019, 8 (04) : 329 - 332
[30] Curcumin enhances bedaquiline's efficacy against Mycobacterium abscessus: in vitro and in vivo evidence
Luo, Dan
Xie, Weile
Wang, Zhe
MICROBIOLOGY SPECTRUM, 2025,

← 1 2 3 4 5 →