Ionic liquid catalyzed one-pot multi-component synthesis, characterization and antibacterial activity of novel chromeno[2,3-d]pyrimidin-8-amine derivatives

被引：38

作者：

Kanakaraju, Sankari ^{[1
]}

Prasanna, Bethanamudi ^{[1
]}

Basavoju, Srinivas ^{[1
]}

Chandramouli, G. V. P. ^{[1
]}

机构：

[1] Natl Inst Technol, Dept Chem, Warangal 506004, Andhra Pradesh, India

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2012年 / 1017卷

关键词：

One-pot synthesis; Multi-component reaction; bmim]BF4; Chromeno[2,3-d]pyrimidin-8-amine; Antibacterial activity; Single-crystal X-ray diffraction; INHIBITORS; APOPTOSIS; COMPOUND; PROTEIN;

D O I：

10.1016/j.molstruc.2012.02.044

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An efficient, simple and convenient method for the one-pot multi-component synthesis of novel chromeno[2,3-d]pyrimidin-8-amine derivatives has been accomplished by starting from alpha-naphthol, aryl aldehydes, malononitrile and NH4Cl. The reaction has been catalyzed by 1-butyl-3-methylimidazolium tetrafluoroborate [bmim]BF4 ionic liquid. The newly synthesized compounds were characterized by IR, H-1 NMR, C-13 NMR, mass spectra, and elemental analysis. The structure of compound 4a was confirmed by single-crystal X-ray diffraction. All the synthesized compounds were evaluated for their in vitro antibacterial activity. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：60 / 64

页数：5

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