Longitudinal CSF Alzheimer's disease biomarker changes from middle age to late adulthood

被引：9

作者：

Pettigrew, Corinne ^{[1
,3
]}

Soldan, Anja ^{[1
]}

Wang, Jiangxia

Wang, Mei-Cheng ^{[2
]}

Greenberg, Barry ^{[1
]}

Albert, Marilyn ^{[1
]}

Moghekar, Abhay ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA

[3] Johns Hopkins Univ, Dept Neurol, Sch Med, 1620 McElderry St,Reed Hall 109, Baltimore, MD 21205 USA

来源：

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2022年 / 14卷 / 01期

基金：

美国国家卫生研究院;

关键词：

amyloid; apolipoprotein E genotype; biomarkers; cerebrospinal fluid; preclinical Alzheimer's disease; tau; CEREBROSPINAL-FLUID BIOMARKER; MILD COGNITIVE IMPAIRMENT; APOLIPOPROTEIN-E GENOTYPE; AMYLOID-BETA; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; SYMPTOM ONSET; APOE GENOTYPE; OLDER-ADULTS;

D O I：

10.1002/dad2.12374

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionWe examined longitudinal cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarker changes among cognitively normal individuals with 10.7 years follow-up, on average. MethodsAnalyses included 278 participants (M age = 57.5 years); 94 have progressed from normal cognition to mild cognitive impairment (MCI). Amyloid beta (A beta)(42)/A beta(40), phosphorylated tau(181) (p-tau(181)), and total tau (t-tau) were measured using automated electrochemiluminescence assays. ResultsApolipoprotein E (APOE) epsilon 4 carriers had lower baseline A beta(42)/A beta(40), but longitudinal A beta(42)/A beta(40) decreases did not differ by APOE epsilon 4 after accounting for A beta(42)/A beta(40) positivity. Lower baseline A beta(42)/A beta(40) was associated with greater increases in tau (more strongly in males), and APOE epsilon 4 genotype was associated with greater tau increases after reaching A beta(42)/A beta(40) positivity. Participants who progressed to MCI had more abnormal biomarker levels and greater tau increases prior to MCI symptom onset. Biomarkers were more abnormal among older adults, but unrelated to sex or education. DiscussionOur results confirm accelerated biomarker changes during preclinical AD and highlight the important role of amyloid levels in tau accelerations.

引用

页数：11

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