The enantioselective total synthesis and unambiguous proof of the absolute stereochemistry of pervilleine C

被引：13

作者：

Kulkarni, Ketav ^{[1
]}

Zhao, Anne Y. ^{[2
]}

Purcell, Anthony W. ^{[2
]}

Perlmutter, Patrick ^{[1
]}

机构：

[1] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia

[2] Univ Melbourne, Dept Biochem & Mol Biol, Bio Mol Sci & Biotechnol Inst 21, Melbourne, Vic 3010, Australia

来源：

SYNLETT | 2008年 / 14期

关键词：

pervilleines; MDR reversal; total synthesis; 4+3] cycloadditions; enantioselective oxidative hydroboration;

D O I：

10.1055/s-2008-1078255

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first enantioselective, total synthesis of the naturally occurring, potent cancer MDR reversal agent pervilleine C is reported. Each enantiomer of the natural product has been prepared as well as the enantiomers of the corresponding 8-oxa-pervilleine C.

引用

页码：2209 / 2212

页数：4

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