Carbon dots as inhibitors of virus by activation of type I interferon response

被引：118

作者：

Du, Ting ^{[1
]}

Liang, Jiangong ^{[1
]}

Dong, Nan ^{[2
]}

Liu, Lin ^{[1
]}

Fang, Liurong ^{[2
]}

Xiao, Shaobo ^{[2
]}

Han, Heyou ^{[1
]}

机构：

[1] Huazhong Agr Univ, Coll Sci, Coll Food Sci & Technol, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China

[2] Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China

来源：

CARBON | 2016年 / 110卷

基金：

中国国家自然科学基金;

关键词：

QUANTUM DOTS; PSEUDORABIES-VIRUS; ANTIVIRAL ACTIVITY; SILVER NANOPARTICLES; NANODOTS; INFECTION; PROTEIN; SURFACE; CHARGE; ENTRY;

D O I：

10.1016/j.carbon.2016.09.032

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Carbon dots (CDs) has shown exciting potential in the field of bioscience and biotechnology due to their low toxicity, biological and ecological friendliness and desirable performance characteristics of quantum dots (QDs). However, the effects of CDs on viruses are still largely unknown. In this study, we investigate the effect of CDs on the replication of virus by using pseudorabies virus (PRV) and porcine reproductive and respiratory syndrome virus (PRRSV) as the models of DNA virus and RNA virus, respectively. Analyses of virus titers and the expression of viral proteins demonstrate that cells treated with CDs can significantly inhibit the multiplication of PRV and PRRSV. In mechanism, CDs treatment dramatically induces interferon-alpha (IFN-alpha) production and the expression of IFN-stimulating genes (ISGs) which in turn inhibits virus replication. Taken together, these results reveal a previously undefined role of CDs and provide a new strategy to develop antiviral agents. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：278 / 285

页数：8

共 67 条

[1] Quantitative Proteomic Analysis Reveals That Transmissible Gastroenteritis Virus Activates the JAK-STAT1 Signaling Pathway [J].

An, Kang ;

Fang, Liurong ;

Luo, Rui ;

Wang, Dang ;

Xie, Lilan ;

Yang, Jing ;

Chen, Huanchun ;

Xiao, Shaobo .

JOURNAL OF PROTEOME RESEARCH, 2014, 13 (12) :5376-5390

[2] Luminescent Carbon Nanodots: Emergent Nanolights [J].

Baker, Sheila N. ;

Baker, Gary A. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (38) :6726-6744

[3] Inhibition of HSV-1 Attachment, Entry, and Cell-to-Cell Spread by Functionalized Multivalent Gold Nanoparticles [J].

Baram-Pinto, Dana ;

Shukla, Sourabh ;

Gedanken, Aharon ;

Sarid, Ronit .

SMALL, 2010, 6 (09) :1044-1050

[4] High Efficiency of Functional Carbon Nanodots as Entry Inhibitors of Herpes Simplex Virus Type 1 [J].

Barras, Alexandre ;

Pagneux, Quentin ;

Sane, Famara ;

Wang, Qi ;

Boukherroub, Rabah ;

Hober, Didier ;

Szunerits, Sabine .

ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (14) :9004-9013

[5] Interferons at age 50: past, current and future impact on biomedicine [J].

Borden, Ernest C. ;

Sen, Ganes C. ;

Uze, Gilles ;

Silverman, Robert H. ;

Ransohoff, Richard M. ;

Foster, Graham R. ;

Stark, George R. .

NATURE REVIEWS DRUG DISCOVERY, 2007, 6 (12) :975-990

[6] Carbon dots for multiphoton bioimaging [J].

Cao, Li ;

Wang, Xin ;

Meziani, Mohammed J. ;

Lu, Fushen ;

Wang, Haifang ;

Luo, Pengju G. ;

Lin, Yi ;

Harruff, Barbara A. ;

Veca, L. Monica ;

Murray, Davoy ;

Xie, Su-Yuan ;

Sun, Ya-Ping .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (37) :11318-+

[7] Interferon-induced inhibition of parainfluenza virus type 5; the roles of MxA, PKR and oligo A synthetase/RNase L [J].

Carlos, T. S. ;

Young, D. ;

Stertz, S. ;

Kochs, G. ;

Randall, R. E. .

VIROLOGY, 2007, 363 (01) :166-173

[8] Synthesis, functionalization and bioimaging applications of highly fluorescent carbon nanoparticles [J].

Chandra, Sourov ;

Das, Pradip ;

Bag, Sourav ;

Laha, Dipranjan ;

Pramanik, Panchanan .

NANOSCALE, 2011, 3 (04) :1533-1540

[9] Full-Color Light-Emitting Carbon Dots with a Surface-State-Controlled Luminescence Mechanism [J].

Ding, Hui ;

Yu, Shang-Bo ;

Wei, Ji-Shi ;

Xiong, Huan-Ming .

ACS NANO, 2016, 10 (01) :484-491

[10] Probing the interactions of CdTe quantum dots with pseudorabies virus [J].

Du, Ting ;

Cai, Kaimei ;

Han, Heyou ;

Fang, Liurong ;

Liang, Jiangong ;

Xiao, Shaobo .

SCIENTIFIC REPORTS, 2015, 5

← 1 2 3 4 5 6 7 →