Mechanisms of synaptic depression triggered by metabotropic glutamate receptors

被引：106

作者：

Bellone, C. ^{[1
]}

Luescher, C. ^{[1
,2
]}

Mameli, M. ^{[1
]}

机构：

[1] Univ Geneva, Fac Med, Dept Basic Neurosci, CH-1211 Geneva, Switzerland

[2] Univ Hosp Geneva, Neurol Clin, Dept Clin Neurosci, CH-1211 Geneva, Switzerland

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 18期

关键词：

long-term depression; synaptic transmission; metabotropic glutamate receptors; AMPA receptors;

D O I：

10.1007/s00018-008-8263-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.

引用

页码：2913 / 2923

页数：11

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