Mechanisms of synaptic depression triggered by metabotropic glutamate receptors

被引：106
作者：
Bellone, C. [1 ]
Luescher, C. [1 ,2 ]
Mameli, M. [1 ]
机构：
[1] Univ Geneva, Fac Med, Dept Basic Neurosci, CH-1211 Geneva, Switzerland
[2] Univ Hosp Geneva, Neurol Clin, Dept Clin Neurosci, CH-1211 Geneva, Switzerland
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 18期
关键词：
long-term depression; synaptic transmission; metabotropic glutamate receptors; AMPA receptors;
D O I：
10.1007/s00018-008-8263-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.
引用
收藏
页码：2913 / 2923
页数：11
相关论文
共 120 条
[91]   The Metabotropic Glutamate Receptors: Structure, Activation Mechanism and Pharmacology [J].
Pin, Jean-Philippe ;
Acher, Francine .
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2002, 1 (03) :297-317
[92]   Group II mGluR-induced long term depression in the dentate gyrus in vivo is NMDA receptor-independent and does not require protein synthesis [J].
Pöschel, B ;
Manahan-Vaughan, D .
NEUROPHARMACOLOGY, 2005, 49 :1-12
[93]   Activation of mGlu receptors induces LTD without affecting postsynaptic sensitivity of CA1 neurons in rat hippocampal slices [J].
Rammes, G ;
Palmer, M ;
Eder, M ;
Dodt, HU ;
Zieglgänsberger, W ;
Collingridge, GL .
JOURNAL OF PHYSIOLOGY-LONDON, 2003, 546 (02) :455-460
[94]   Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens [J].
Robbe, D ;
Kopf, M ;
Remaury, A ;
Bockaert, J ;
Manzoni, OJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) :8384-8388
[95]   Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation [J].
Ronesi, Jennifer A. ;
Huber, Kimberly M. .
JOURNAL OF NEUROSCIENCE, 2008, 28 (02) :543-547
[96]   Endocannabinoids contribute to short-term but not long-term mGluR-induced depression in the hippocampus [J].
Rouach, N ;
Nicoll, RA .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 18 (04) :1017-1020
[97]   Endocannabinoids control the induction of cerebellar LTD [J].
Safo, PK ;
Regehr, WG .
NEURON, 2005, 48 (04) :647-659
[98]   Activation of receptors negatively coupled to adenylate cyclase is required for induction of long-term synaptic depression at Schaffer collateral-CA1 synapses [J].
Santschi, LA ;
Zhang, XL ;
Stanton, PK .
JOURNAL OF NEUROBIOLOGY, 2006, 66 (03) :205-219
[99]   Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors [J].
Scanziani, M ;
Salin, PA ;
Vogt, KE ;
Malenka, RC ;
Nicoll, RA .
NATURE, 1997, 385 (6617) :630-634
[100]   cAMP-cependent protein kinase inhibits mGluR2 coupling to G-proteins by direct receptor phosphorylation [J].
Schaffhauser, H ;
Cai, ZH ;
Hubalek, F ;
Macek, TA ;
Pohl, J ;
Murphy, TJ ;
Conn, PJ .
JOURNAL OF NEUROSCIENCE, 2000, 20 (15) :5663-5670
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