Mechanisms of synaptic depression triggered by metabotropic glutamate receptors

被引：103
作者：
Bellone, C. [1 ]
Luescher, C. [1 ,2 ]
Mameli, M. [1 ]
机构：
[1] Univ Geneva, Fac Med, Dept Basic Neurosci, CH-1211 Geneva, Switzerland
[2] Univ Hosp Geneva, Neurol Clin, Dept Clin Neurosci, CH-1211 Geneva, Switzerland
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 18期
关键词：
long-term depression; synaptic transmission; metabotropic glutamate receptors; AMPA receptors;
D O I：
10.1007/s00018-008-8263-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.
引用
收藏
页码：2913 / 2923
页数：11
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