Estimating relative bioavailability of soil lead in the mouse

被引：28

作者：

Bradham, Karen D. ^{[1
]}

Green, William ^{[2
]}

Hayes, Hunter ^{[2
]}

Nelson, Clay ^{[1
]}

Alava, Pradeep ^{[3
]}

Misenheimer, John ^{[4
]}

Diamond, Gary L. ^{[5
]}

Thayer, William C. ^{[5
]}

Thomas, David J. ^{[2
]}

机构：

[1] US EPA, Publ Hlth Chem Branch, Exposure Methods & Measurements Div, Natl Exposure Res Lab,Off Res & Dev, Res Triangle Pk, NC 27709 USA

[2] US EPA, Pharmacokinet Branch, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA

[3] Natl Res Associateship Programs, Res Triangle Pk, NC USA

[4] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC USA

[5] SRC Inc, North Syracuse, NY USA

来源：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES | 2016年 / 79卷 / 24期

关键词：

CONTAMINATED SOILS; RATS; BIOACCESSIBILITY; SWINE;

D O I：

10.1080/15287394.2016.1221789

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Lead (Pb) in soil is an important exposure source for children. Thus, determining bioavailability of Pb in soil is critical in evaluating risk and selecting appropriate strategies to minimize exposure. A mouse model was developed to estimate relative bioavailability of Pb in NIST SRM 2710a (Montana 1 Soil). Based on Pb levels in tissues, the mean relative bioavailability of this metal in this soil was 0.5. Estimates of relative bioavailabilities derived from mouse compared favorably with those obtained in juvenile swine. The mouse model is thus an efficient and inexpensive method to obtain estimates of relative bioavailability of soil Pb.

引用

页码：1179 / 1182

页数：4

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