Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives

被引：35

作者：

Borgia, Francesco ^{[1
]}

Li Pomi, Federica ^{[1
]}

Vaccaro, Mario ^{[1
]}

Alessandrello, Clara ^{[2
]}

Papa, Vincenzo ^{[2
]}

Gangemi, Sebastiano ^{[2
]}

机构：

[1] Univ Messina, Dept Clin & Expt Med, Sect Dermatol, I-98125 Messina, Italy

[2] Univ Messina, Sch & Operat Unit Allergy & Clin Immunol, Dept Clin & Expt Med, I-98125 Messina, Italy

来源：

BIOMOLECULES | 2022年 / 12卷 / 12期

关键词：

atopic dermatitis; oxidative stress; phototherapy; reactive oxygen species; ultraviolet; UVB; UVA; PON1; NRF2; skin disease; SKIN; EXPRESSION; INFLAMMATION; MODULATION; BIOMARKERS; MANAGEMENT; EFFICACY; SAFETY;

D O I：

10.3390/biom12121904

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Atopic dermatitis is a chronic inflammatory skin disease in which the overproduction of reactive oxygen species plays a pivotal role in the pathogenesis and persistence of inflammatory lesions. Phototherapy represents one of the most used therapeutic options, with benefits in the clinical picture. Studies have demonstrated the immunomodulatory effect of phototherapy and its role in reducing molecule hallmarks of oxidative stress. In this review, we report the data present in literature dealing with the main signaling molecular pathways involved in oxidative stress after phototherapy to target atopic dermatitis-affected cells. Since oxidative stress plays a pivotal role in the pathogenesis of atopic dermatitis and its flare-up, new research lines could be opened to study new drugs that act on this mechanism, perhaps in concert with phototherapy.

引用

页数：13

共 91 条

[1] Overview of the Mechanisms of Oxidative Stress: Impact in Inflammation of the Airway Diseases [J].