Autophagy at synapses in neurodegenerative diseases

被引：22

作者：

Lee, Wongyoung ^{[1
]}

Kim, Sung Hyun ^{[2
,3
,4
]}

机构：

[1] Kyung Hee Univ, Dept Neurosci, Grad Sch, Seoul 02447, South Korea

[2] Kyung Hee Univ, Dept Physiol, Sch Med, Seoul 02447, South Korea

[3] Kyung Hee Univ, Med Res Ctr Bioreact React Oxygen Species, Sch Med, Seoul 02447, South Korea

[4] Kyung Hee Univ, Inst Biomed Sci, Seoul 02447, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2019年 / 42卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Autophagy; Synapse; Synaptic transmission; Synaptic retrieval; Alzheimer's disease; Parkinson's disease; CHAPERONE-MEDIATED AUTOPHAGY; SYNAPTIC VESICLE ENDOCYTOSIS; ALPHA-SYNUCLEIN; ALZHEIMERS-DISEASE; PARKINSON DISEASE; PROMOTES; ENDOPHILIN; LRRK2; DEGRADATION; PROTEIN;

D O I：

10.1007/s12272-019-01148-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Autophagy is an essential process for maintaining cellular homeostasis, a critical process in all cell types. Because neurons are post-mitotic cells, maintaining cellular and functional homeostasis is more important in neurons than in other types of cells. Synapses are fundamental units needed for neural communication, and synapses with consistent protein quality are essential for neural functionality. Dysregulation of autophagy in neurons has been shown to be related to neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. This review describes the role of autophagy in the maintenance of synaptic functionality and the association between synaptic autophagy and neurodegenerative diseases.

引用

页码：407 / 415

页数：9

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