Human leukocyte elastase counteracts matrix metalloproteinase-7 induced apoptosis resistance of tumor cells

被引：9

作者：

Alla, Vijay ^{[1
]}

Kashyap, Anubha ^{[1
]}

Gregor, Sebastian ^{[1
]}

Theobald, Matthias ^{[2
]}

Heid, Hans ^{[3
]}

Galle, Peter R. ^{[1
]}

Strand, Dennis ^{[1
]}

Strand, Susanne ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Dept Internal Med 1, D-55101 Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Dept Internal Med 3, D-55101 Mainz, Germany

[3] German Canc Res Ctr, Dept Cell Biol, D-69120 Heidelberg, Germany

来源：

CANCER LETTERS | 2008年 / 268卷 / 02期

关键词：

MMP-7; neutrophil elastase; apoptosis resistance; cytotoxic T lymphocytes; chemotherapy;

D O I：

10.1016/j.canlet.2008.04.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Matrix metalloproteinase-7 (MMP-7/Matrilysin) is a component of the tumor microenvironment associated with malignant progression. Its expression in tumors protects tumor cells from CD95-mediated apoptosis and the cytotoxic activity of tumor specific CD8(+) T cells. In the present study, we show that human leukocyte elastase (HLE) secreted by polymorphonuclear leukocytes cleaves MMP-7 resulting in loss of enzymatic activity. The anti-apoptotic effect of MMP-7 is reduced in the presence of HLE for CD95-, doxorubicin- and CTL-mediated apoptosis. Our data indicates that HLE may be a natural inactivator of MMP-7 which can counteract MMP-7-induced apoptosis resistance. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：331 / 339

页数：9

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