Is there an association between the COMT gene and P300 endophenotypes?

被引：42

作者：

Bramon, E ^{[1
]}

Dempster, E ^{[1
]}

Frangou, S ^{[1
]}

McDonald, C ^{[1
]}

Schoenberg, P ^{[1
]}

MacCabe, JH ^{[1
]}

Walshe, M ^{[1
]}

Sham, P ^{[1
]}

Collier, D ^{[1
]}

Murray, RM ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, London SE5 8AF, England

来源：

EUROPEAN PSYCHIATRY | 2006年 / 21卷 / 01期

基金：

英国惠康基金;

关键词：

neurophysiology; schizophrenia; biological marker; endophenotype; P300; COMT gene;

D O I：

10.1016/j.eurpsy.2005.11.001

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

P300 wave anomalies correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The COMT gene is thought to influence cognitive performance and to be a susceptibility gene for schizophrenia. Unlike two previous studies, we found no significant influence of the COMT gene on P300 amplitude or latency in 189 individuals examined. The well-supported role of the COMT gene both in dopamine catabolism as well as in prefrontal cognition makes a strong theoretical case for the influence of COMT Va1158Met polymorphism on P300 endophenotypes. However, the available neurophysiologic evidence suggests that any Such association, if present, must be very subtle. (c) 2006 Elsevier SAS. All rights reserved.

引用

页码：70 / 73

页数：4

共 27 条

[1]

BLACKWOOD DHR, 1991, ARCH GEN PSYCHIAT, V48, P899

[2] Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study [J].

Bramon, E ;

McDonald, C ;

Croft, RJ ;

Landau, S ;

Filbey, F ;

Gruzelier, JH ;

Sham, PC ;

Frangou, S ;

Murray, RM .

NEUROIMAGE, 2005, 27 (04) :960-968

[3] Mismatch negativity in schizophrenia: a family study [J].

Bramon, E ;

Croft, RJ ;

McDonald, C ;

Virdi, GK ;

Gruzelier, JG ;

Baldeweg, T ;

Sham, PC ;

Frangou, S ;

Murray, RM .

SCHIZOPHRENIA RESEARCH, 2004, 67 (01) :1-10

[4] Meta-analysis of the P300 and P50 waveforms in schizophrenia [J].

Bramon, E ;

Rabe-Hesketh, S ;

Sham, P ;

Murray, RM ;

Frangou, S .

SCHIZOPHRENIA RESEARCH, 2004, 70 (2-3) :315-329

[5]

DEMPSTER E, UNPUB ASS COMT VALL5

[6] Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia [J].

Egan, MF ;

Goldberg, TE ;

Kolachana, BS ;

Callicott, JH ;

Mazzanti, CM ;

Straub, RE ;

Goldman, D ;

Weinberger, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (12) :6917-6922

[7]

ENDICOTT J, 1978, ARCH GEN PSYCHIAT, V35, P837

[8] Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: A large-scale association study plus meta-analysis [J].

Fan, JB ;

Zhang, CS ;

Gu, NF ;

Li, XW ;

Sun, WW ;

Wang, HY ;

Feng, GY ;

Clair, DS ;

He, L .

BIOLOGICAL PSYCHIATRY, 2005, 57 (02) :139-144

[9] The Maudsley family study .2. Endogenous event-related potentials in familial schizophrenia [J].

Frangou, S ;

Sharma, T ;

Alarcon, G ;

Sigmudsson, T ;

Takei, N ;

Binnie, C ;

Murray, RM .

SCHIZOPHRENIA RESEARCH, 1997, 23 (01) :45-53

[10] Effects of violations of assumptions on likelihood methods for estimating the penetrance of an autosomal dominant mutation from kin-cohort studies [J].

Gail, MH ;

Pee, D ;

Carroll, R .

JOURNAL OF STATISTICAL PLANNING AND INFERENCE, 2001, 96 (01) :167-177

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