Convenient method for 14C-labelling of a series of (E)-Styrylamidines as NR2B-selective NMDA receptor antagonist

被引：0

作者：

Saemian, Nader ^{[1
]}

Esmailli, Kameh ^{[2
]}

Shirvani, Gholamhossein ^{[1
]}

Payehghadr, Mahmood ^{[3
]}

Javaheri, Mohsen ^{[1
]}

Arjomandi, Omid Khalili ^{[1
]}

机构：

[1] Nucl Sci & Technol Res Inst, Nucl Sci Res Sch, Tehran, Iran

[2] Abhar Payame Noor Univ, Dept Chem, Zanjan, Iran

[3] Karaj Payame Noor Univ, Dept Chem, Karaj, Iran

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2012年 / 292卷 / 01期

关键词：

Carbon-14; (E)-3-aryl-acrylonitrile; NMDA receptor; NR2B SUBUNIT; C-14; ANALOG; DIIODOMETHANE; BRAIN;

D O I：

10.1007/s10967-011-1463-6

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A series of (E)-Styrylamidines labeled with carbon-14 in the 1-position, were prepared from (E)-3-aryl-acrylonitrile-[cyano-C-14] as a key synthetic intermediate which has been synthesized from E-beta-aryl-vinyl iodides and zinc [C-14]-cyanide in the presence of tetrakis(triphenylphosphine)palladium.

引用

页码：85 / 88

页数：4

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