Simultaneous Presentation of Waldenstrom's Macroglobulinemia and MYD88 Gene Mutation with Multiple Myeloma

被引:0
作者
Awada, Hassan [1 ]
Kewan, Tariq [1 ]
Covut, Fahrettin [1 ]
Daw, Hamed [2 ]
Haddad, Abdo [2 ]
机构
[1] Cleveland Clin, Fairview Hosp, Internal Med, Cleveland, OH 44106 USA
[2] Cleveland Clin, Fairview Hosp, Hematol & Oncol, Cleveland, OH 44106 USA
关键词
waldenstrom macroglobulinemia; multiple myeloma; myd88 gene mutation; b-cell neoplasms; CXCR4; MUTATIONS; L265P MUTATION; DIAGNOSIS; IDENTIFY;
D O I
10.7759/cureus.3822
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Waldenstrom's macroglobulinemia (WM) and multiple myeloma (MM) are two distinct forms of mature hematologic B-cell malignancies. a missense somatic mutation in MYD88 gene (MYD88L265P) has been found in hematologic B-cell malignancies. The simultaneous presentation of Waldenstrom's macroglobulinemia and MYD88 mutation with multiple myeloma in the same patient is very rare and only a few cases have been reported in the literature.
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