Dimethyl-β-cyclodextrin/salazosulfapyridine inclusion complex-loaded chitosan nanoparticles for sustained release

被引：26

作者：

Tang, Peixiao ^{[1
]}

Yang, Hongqin ^{[1
]}

Tang, Bin ^{[1
]}

Wu, Di ^{[1
]}

Du, Qiaohong ^{[1
]}

Xu, Kailin ^{[1
]}

Li, Hui ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem Engn, Chengdu 610065, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2017年 / 156卷

关键词：

Salazosufapyridine; 2,6-dimethyl-beta-cyclodextrin; Chitosan; Nanoparticles; Sustained release; RHEUMATOID-ARTHRITIS; NMR-SPECTROSCOPY; CYCLODEXTRIN; SULFASALAZINE; DELIVERY; DISSOLUTION; 2,6-DI-O-METHYL-BETA-CYCLODEXTRIN; MANAGEMENT; SYSTEM;

D O I：

10.1016/j.carbpol.2016.09.038

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This study aimed to investigate a novel delivery system for salazosulfapyridine (SASP) through encapsulation in 2,6-dimethyl-beta-cyclodextrin (DM beta CD) and further incorporation in chitosan (CS) to form nanoparticles (NPs). The inclusion complex of SASP and DM beta CD was prepared at 1:1 host-guest stoichiometry based on Job's plot and then characterized through various analytical techniques. Then, the DM beta CD/SASP inclusion complex was incorporated in CS to form DM beta CD/SASP/CS NPs. The loading efficiency of SASP in the DM beta CD/SASP/CS NPs was significantly higher than that of the SASP/CS NPs. A positive zeta potential of +35.4 mV was also observed in the DM beta CD/SASP/CS NPs with an average size of 90 nm. SASP exhibited a sustained release after the DM beta CD/SASP/CS NPs were formed. The toxicity of the NPs to LO2 cells was lower than that of free SASP. Therefore, the CD inclusion complex-loaded CS NPs can be applied to deliver hydrophobic drugs. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：215 / 222

页数：8

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