Synthesis of 1-hydroxypyrazole glycine derivatives

被引：14
作者：
Calí, P [1 ]
Begtrup, M [1 ]
机构：
[1] Royal Danish Sch Pharm, Dept Med Chem, DK-2100 Copenhagen, Denmark
来源：
TETRAHEDRON | 2002年 / 58卷 / 08期
关键词：
arylglycine; amino acid; 1-hydroxypyrazole; imino malonate;
D O I：
10.1016/S0040-4020(02)00021-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of novel alpha-amino acids containing the 1-hydroxypyrazole ring has been prepared by addition of organomagnesium or organolithium intermediates to diethyl N-Boc-iminomalonate as an electrophilic glycine equivalent. Electrophiles, aryl and heteroaryl substituents were introduced in the pyrazole ring. (C) 2002 Published by Elsevier Science Ltd.
引用
收藏
页码：1595 / 1605
页数：11
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