Is asthma control more than just an absence of symptoms? An expert consensus statement

被引：9

作者：

Canonica, Giorgio Walter ^{[1
]}

Spanevello, Antonio ^{[2
,3
]}

Ribas, Christian Domingo ^{[5
]}

Blakey, John D. ^{[6
,7
]}

Garcia, Gabriel ^{[8
]}

Inoue, Hiromasa ^{[9
]}

Dalcolmo, Margareth ^{[10
]}

Yang, Dong ^{[11
]}

Mokashi, Soniya ^{[12
]}

Kurne, Abhishek ^{[13
]}

Llano, Luis Perez de ^{[4
]}

Butta, Aman Kapil ^{[1
,14
]}

机构：

[1] Humanitas Univ, Humanitas Res Hosp IRCCS, Personalized Med Asthma & Allergy Clin, Milan, Italy

[2] Univ Insubria, Dipartimento Med & Chirurg, Varese, Italy

[3] IRCCS Tradate, Dipartimento Med & Riabilitaz Cardiorespiratoria, Isti Clin Sci Maugeri, Varese, Italy

[4] Hosp Univ Lucus Augusti, Pneumol Serv, EOXI Lugo, Cervo Monforte, Spain

[5] Univ Autonoma Barcelona UAB, Pulm Serv, Corporacio Sanitaria Parc Tauli, Sabadell, Spain

[6] Sir Charles Gairdner Hosp, Resp Med, Nedlands, WA, Australia

[7] Curtin Univ, Med Sch, Perth, Australia

[8] Hosp R Rossi, Pulm Serv, Pneumol, Plata, Argentina

[9] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Pulm Med, Kagoshima, Japan

[10] Fundacao Oswaldo Cruz Fiocruz Minist Hlth, Reference Ctr Helio Fraga, Rio De Janeiro, Brazil

[11] Fudan Univ, Zhongshan Hosp, Dept Pulm Med, Shanghai, Peoples R China

[12] GSK Brentford, Middlesex, England

[13] Global Med Affairs, GSK, Asia House, Singapore

[14] GSK, Asia House, Singapore

来源：

RESPIRATORY MEDICINE | 2022年 / 202卷

关键词：

Asthma; Asthma control; Delphi consensus; Exacerbations; Quality of life; Symptom control; QUESTIONNAIRE; EXACERBATIONS; GUIDELINES;

D O I：

10.1016/j.rmed.2022.106942

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: Definitions and measures of asthma control used in clinical trials and in clinical practice vary considerably. There is also misalignment between patients and healthcare professionals (HCPs) in terms of understanding and managing asthma control. This study aimed to progress towards a consensus definition of asthma control, and evaluate disparities between HCP and patient perspectives. Basic procedures: A two-stage Delphi questionnaire involving asthma specialists sought to identify areas of consensus on aspects of asthma control in clinical practice. Results were compared with those of a structured literature review to assess if existing guidance and measures of asthma control used in studies correlated with practice. Eighty-two panelists took part in the Delphi questionnaire. The structured literature review included 185 manuscripts and 31 abstracts. Main findings: Panelists agreed that there was no standard definition of asthma control, confirmed by a total of 19 different composite consensus/guideline definitions and/or validated measures of control being identified across the Delphi study and literature review. Panelists agreed on the positive associations of well-controlled asthma with patient outcomes, but not on the components or thresholds of a working definition of control. Principal conclusions: A universally accepted definition and measure of asthma control that is utilized and understood by patients, HCPs, and researchers is required.

引用

页数：9

共 22 条

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