Influence of Bariatric Surgery on the Use and Pharmacokinetics of Some Major Drug Classes

被引：45
作者：
Yska, Jan Peter [1 ]
van der Linde, Susanne [1 ]
Tapper, Veronique V. [1 ]
Apers, Jan A. [2 ]
Emous, Marloes [2 ]
Totte, Erik R. [2 ]
Wilffert, Bob [3 ,4 ]
van Roon, Eric N. [1 ]
机构：
[1] Med Ctr Leeuwarden, Dept Clin Pharm & Clin Pharmacol, NL-8901 BR Leeuwarden, Netherlands
[2] Med Ctr Leeuwarden, Dept Surg, NL-8901 BR Leeuwarden, Netherlands
[3] Univ Groningen, Dept Pharm, Unit Pharmacotherapy & Pharmaceut Care, Groningen, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, Dept Hosp & Clin Pharm, Groningen, Netherlands
来源：
OBESITY SURGERY | 2013年 / 23卷 / 06期
关键词：
Bariatric surgery; Pharmacoepidemiology; Pharmacokinetics; Drug class; GASTRIC BYPASS-SURGERY; TYPE-2; DIABETES-MELLITUS; MORBIDLY OBESE-PATIENTS; BILIOPANCREATIC DIVERSION; SYSTEMIC EXPOSURE; MEDICAL THERAPY; WEIGHT; COSTS; BENEFITS; IMPACT;
D O I：
10.1007/s11695-013-0882-6
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The purpose of this review is to evaluate the influence of bariatric surgery on the use and pharmacokinetics of some frequently used drugs. A PubMed literature search was conducted. Literature was included on influence of bariatric surgery on pharmacoepidemiology and pharmacokinetics. Drug classes to be searched for were antidepressants, antidiabetics, statins, antihypertensive agents, corticosteroids, oral contraceptives, and thyroid drugs. A reduction in the use of medication by patients after bariatric surgery has been reported for various drug classes. Very few studies have been published on the influence of bariatric surgery on the pharmacokinetics of drugs. After bariatric surgery, theoretically, reduced drug absorption may occur. Correct dosing and choosing the right dosage form for drugs used by patients after bariatric surgery are necessary for optimal pharmacotherapy. Therefore, more clinical studies are needed on the influence of bariatric surgery on the pharmacokinetics of major drugs.
引用
收藏
页码：819 / 825
页数：7
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