Cesium-Carbonate-Mediated Benzalation of Substituted 2-Aryl-3-nitro-2H-chromenes with Substituted 4-Benzylidene-2-phenyloxazol-5(4H)-ones

被引：14

作者：

Dai, Chenlu ^{[1
]}

Luo, Naili ^{[1
]}

Wang, Shan ^{[1
]}

Wang, Cunde ^{[1
]}

机构：

[1] Yangzhou Univ, Sch Chem & Chem Engn, 180 Siwangting St, Yangzhou 225002, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 08期

基金：

中国国家自然科学基金;

关键词：

3-NITRO-2-TRIHALOMETHYL-2H-CHROMENES;

D O I：

10.1021/acs.orglett.9b00776

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cs2CO3-mediated domino benzalation reaction with a variety of 2-aryl-3-nitro-2H-chromenes and 4-benzylidene-2-phenyloxazol-5(4H)-ones has been realized. The reaction proceeds smoothly with a broad substrate scope, thus providing a variety of substituted (Z)-4-((Z)-benzylidene)chroman-3-one oximes in moderate to high yields, which were easily transformed into biologically important 4H-chromeno[3,4-c]isoxazoles.

引用

页码：2828 / 2832

页数：5

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