SOHO State of the Art Updates and Next Questions: Prophylaxis and Management of Secondary CNS Lymphoma

被引：3

作者：

Simard, Jillian ^{[1
]}

Roschewski, Mark ^{[1
,2
]}

机构：

[1] NCI, Ctr Canc Res, Lymphoid Malignancies Branch, Bethesda, MD USA

[2] NCI, Ctr Canc Res, Lymphoid Malignancies Branch, Bethesda, MD 20892 USA

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2022年 / 22卷 / 10期

关键词：

Diffuse large B-cell lymphoma; CNS prophylaxis; Methotrexate; Targeted therapy; Chemotherapy; CENTRAL-NERVOUS-SYSTEM; B-CELL LYMPHOMA; NON-HODGKIN-LYMPHOMA; HIGH-DOSE METHOTREXATE; CEREBROSPINAL-FLUID; INTENSIVE CHEMOTHERAPY; AGGRESSIVE LYMPHOMA; PROGNOSTIC-FACTORS; BURKITT-LYMPHOMA; RISK-FACTORS;

D O I：

10.1016/j.clml.2022.06.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Secondary CNS lymphoma (SCNSL) is a rare but frequently fatal complication of systemic lymphoma. There is no standard treatment for SCNSL, and patients who develop SCNSL at diagnosis or after frontline therapy often receive highly intensive chemotherapy regimens that are inactive against primary chemorefractory disease and too toxic for older, frail patients to tolerate. Because the prognosis of SCNSL is so poor, management has historically emphasized prevention, but the current methods of CNS prophylaxis are not universally effective. To improve both the prevention and management of SCNSL, better characterization of the molecular determinants of CNS invasion is needed. Novel treatments that are currently being studied in SCNSL include targeted pathway inhibitors and cellular therapy, but SCNSL patients are often excluded from clinical trials of promising new therapies.

引用

页码：709 / 717

页数：9

共 116 条

[1] Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study [J].

Abramson, Jeremy S. ;

Palomba, M. Lia ;

Gordon, Leo I. ;

Lunning, Matthew A. ;

Wang, Michael ;

Arnason, Jon ;

Mehta, Amitkumar ;

Purev, Enkhtsetseg ;

Maloney, David G. ;

Andreadis, Charalambos ;

Sehgal, Alison ;

Solomon, Scott R. ;

Ghosh, Nilanjan ;

Albertson, Tina M. ;

Garcia, Jacob ;

Kostic, Ana ;

Mallaney, Mary ;

Ogasawara, Ken ;

Newhall, Kathryn ;

Kim, Yeonhee ;

Li, Daniel ;

Siddiqi, Tanya .

LANCET, 2020, 396 (10254) :839-852

[2] Pivotal Safety and Efficacy Results from Transcend NHL 001, a Multicenter Phase 1 Study of Lisocabtagene Maraleucel (liso-cel) in Relapsed/Refractory ( R/R) Large B Cell Lymphomas [J].

Abramson, Jeremy S. ;

Palomba, Maria Lia ;

Gordon, Leo I. ;

Lunning, Matthew A. ;

Wang, Michael L. ;

Arnason, Jon E. ;

Mehta, Amitkumar ;

Purev, Enkhtsetseg ;

Maloney, David G. ;

Andreadis, Charalambos ;

Sehgal, Alison R. ;

Solomon, Scott R. ;

Ghosh, Nilanjan ;

Albertson, Tina ;

Garcia, Jacob ;

Kostic, Ana ;

Li, Daniel ;

Kim, Yeonhee ;

Siddiqi, Tanya .

BLOOD, 2019, 134

[3] Intravenous Methotrexate as Central Nervous System (CNS) Prophylaxis Is Associated With a Low Risk of CNS Recurrence in High-Risk Patients With Diffuse Large B-Cell Lymphoma [J].

Abramson, Jeremy S. ;

Hellmann, Matthew ;

Barnes, Jeffrey A. ;

Hammerman, Peter ;

Toomey, Christiana ;

Takvorian, Tak ;

Muzikansky, Alona ;

Hochberg, Ephraim P. .

CANCER, 2010, 116 (18) :4283-4290

[4] CAR T-cell therapy for secondary CNS DLBCL [J].

Ahmed, Gulrayz ;

Hamadani, Mehdi ;

Shah, Nirav N. .

BLOOD ADVANCES, 2021, 5 (24) :5626-5630

[5] HIV-associated Burkitt lymphoma: outcomes from a US-UK collaborative analysis [J].

Alderuccio, Juan Pablo ;

Olszewski, Adam J. ;

Evens, Andrew M. ;

Collins, Graham P. ;

Danilov, Alexey, V ;

Bower, Mark ;

Jagadeesh, Deepa ;

Zhu, Catherine ;

Sperling, Amy ;

Kim, Seo-Hyun ;

Vaca, Ryan ;

Wei, Catherine ;

Sundaram, Suchitra ;

Reddy, Nishitha ;

Dalla Pria, Alessia ;

D'Angelo, Christopher ;

Farooq, Umar ;

Bond, David A. ;

Berg, Stephanie ;

Churnetski, Michael C. ;

Godara, Amandeep ;

Khan, Nadia ;

Choi, Yun Kyong ;

Kassam, Shireen ;

Yazdy, Maryam ;

Rabinovich, Emma ;

Post, Frank A. ;

Varma, Gaurav ;

Karmali, Reem ;

Burkart, Madelyn ;

Martin, Peter ;

Ren, Albert ;

Chauhan, Ayushi ;

Diefenbach, Catherine ;

Straker-Edwards, Allandria ;

Klein, Andreas ;

Blum, Kristie A. ;

Boughan, Kirsten Marie ;

Mian, Agrima ;

Haverkos, Bradley M. ;

Orellana-Noia, Victor M. ;

Kenkre, Vaishalee P. ;

Zayac, Adam ;

Maliske, Seth M. ;

Epperla, Narendranath ;

Caimi, Paolo ;

Smith, Scott E. ;

Kamdar, Manali ;

Venugopal, Parameswaran ;

Feldman, Tatyana A. .

BLOOD ADVANCES, 2021, 5 (14) :2852-2862

[6] Combination immunotherapy as a non-chemotherapy alternative for refractory or recurrent CNS lymphoma [J].

Ambady, Prakash ;

Szidonya, Laszlo ;

Firkins, Jenny ;

James, Jessica ;

Johansson, Kirsten ;

White, Tricia ;

Jezierski, Caroline ;

Doolittle, Nancy D. ;

Neuwelt, Edward A. .

LEUKEMIA & LYMPHOMA, 2019, 60 (02) :515-518

[7]

[Anonymous], STUDY NIVOLUMAB RELA

[8]

[Anonymous], B CELL LYMPHOMAS VER

[9] CNS relapse in patients with DLBCL treated with lenalidomide plus R-CHOP (R2CHOP): analysis from two phase 2 studies [J].

Ayed, Ayed O. ;

Chiappella, Annalisa ;

Pederson, Levi ;

Laplant, Betsy R. ;

Congiu, Angela Giovanna ;

Gaidano, Gianluca ;

Spina, Michele ;

Re, Alessandro ;

Cavallo, Federica ;

Musuraca, Gerardo ;

Macon, William R. ;

Witzig, Thomas ;

Vitolo, Umberto ;

Nowakowski, Grzegorz S. .

BLOOD CANCER JOURNAL, 2018, 8

[10] Dose-Adjusted EPOCH-R Compared With R-CHOP as Frontline Therapy for Diffuse Large B-Cell Lymphoma: Clinical Outcomes of the Phase III Intergroup Trial Alliance/CALGB 50303 [J].

Bartlett, Nancy L. ;

Wilson, Wyndham H. ;

Jung, Sin-Ho ;

Hsi, Eric D. ;

Maurer, Matthew J. ;

Pederson, Levi D. ;

Polley, Mei-Yin C. ;

Pitcher, Brandelyn N. ;

Cheson, Bruce D. ;

Kahl, Brad S. ;

Friedberg, Jonathan W. ;

Staudt, Louis M. ;

Wagner-Johnston, Nina D. ;

Blum, Kristie A. ;

Abramson, Jeremy S. ;

Reddy, Nishitha M. ;

Winter, Jane N. ;

Chang, Julie E. ;

Gopal, Ajay K. ;

Chadburn, Amy ;

Mathew, Susan ;

Fisher, Richard I. ;

Richards, Kristy L. ;

Schoder, Heiko ;

Zelenetz, Andrew D. ;

Leonard, John P. .

JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (21) :1790-+

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