Total synthesis of the natural product EBC-329

被引：9

作者：

Thombal, Raju S. ^{[1
]}

Jadhav, Vrushali H. ^{[1
]}

机构：

[1] CSIR, Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 36期

关键词：

TERRESTRIAL ORIGIN; CASBANE DITERPENOIDS; BIOLOGICAL-ACTIVITY; CROTON-INSULARIS; PHORBOL ESTERS; SOFT CORAL;

D O I：

10.1039/c5ob01276g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of an anti-leukemic diterpene natural product EBC-329 (1) has been accomplished starting from readily available 6,6-dimethyl-3-oxabicyclo[3.1.0] hexane-2,4-dione (7). An efficient and general approach has been reported for the synthesis of EBC-329 in 13 steps with an overall yield of 10%.

引用

页码：9485 / 9491

页数：7

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