Electrochemical determination of guanosine 5′-monophosphate using the electropolymerized film of non-peripheral amine substituted nickel(II) phthalocyanine modified electrode

被引：14

作者：

Jeevagan, A. John ^{[1
]}

John, S. Abraham ^{[1
]}

机构：

[1] Gandhigram Rural Inst, Dept Chem, Ctr Nanosci & Nanotechnol, Gandhigram 624302, Dindigul, India

来源：

ELECTROCHIMICA ACTA | 2013年 / 95卷

关键词：

Non-peripheral amine substituted nickel(II) phthalocyanine; Glassy carbon electrode; Guanosine 5 '-monophosphate; Guanine; Differential pulse voltammetry; GUANOSINE-5'-MONOPHOSPHATE; GUANOSINE-5-MONOPHOSPHATE; GUANINE; GMP;

D O I：

10.1016/j.electacta.2013.02.025

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

This paper describes that the glassy carbon electrode (GCE) modified with a polymer film of non-peripheral amine substituted nickel(II) phthalocyanine (p-4 alpha-Ni(II)TAPc) can be used for the selective and stable determination of guanosine 5'-monophosphate (GMP) in phosphate buffer (pH 4) solution. Bare GCE oxidizes GMP at 1.26 V whereas p-4 alpha-Ni(II)TAPc modified GCE oxidizes it at 1.19 V with enhanced oxidation current. Further, the polymer modified electrode selectively determines GMP in the presence of 400-fold higher concentration of guanine. In differential pulse voltammetry measurements, the current response of GMP was linearly increased with the concentration range of 0.005-1 mM. The experimental detection limit was found to be 5 x 10(-6) M. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：246 / 250

页数：5

共 18 条

[1] STUDIES WITH GUANOSINE-5'-MONOPHOSPHATE (GMP) - NEW METHOD FOR MEASUREMENT AND EFFECTS ON BLOOD-PRESSURE [J].