High-Resolution Peripheral Quantitative Computed Tomography for the Assessment of Bone Strength and Structure: A Review by the Canadian Bone Strength Working Group

被引：151

作者：

Cheung, Angela M. ^{[1
,2
]}

Adachi, Jonathan D. ^{[3
]}

Hanley, David A. ^{[4
]}

Kendler, David L. ^{[5
]}

Davison, K. Shawn ^{[6
]}

Josse, Robert ^{[7
]}

Brown, Jacques P. ^{[8
]}

Ste-Marie, Louis-Georges ^{[9
]}

Kremer, Richard ^{[10
]}

Erlandson, Marta C. ^{[7
,11
]}

Dian, Larry ^{[5
]}

Burghardt, Andrew J. ^{[12
]}

Boyd, Steven K. ^{[13
]}

机构：

[1] Univ Toronto, Dept Med, Ctr Excellence Skeletal Hlth Assessment, Toronto, ON, Canada

[2] Univ Toronto, Univ Hlth Network, Joint Dept Med Imaging, Toronto, ON, Canada

[3] St Josephs Healthcare McMaster Univ, Michael G DeGroote Sch Med, Dept Med, Hamilton, ON, Canada

[4] Univ Calgary, Dept Med, Calgary, AB T2N 4Z6, Canada

[5] Univ British Columbia, Dept Med, Vancouver, BC, Canada

[6] Univ Victoria, Victoria, BC, Canada

[7] Univ Toronto, Dept Med, Toronto, ON, Canada

[8] Univ Laval, Dept Med, Quebec City, PQ G1K 7P4, Canada

[9] Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada

[10] McGill Univ, Dept Med, Montreal, PQ, Canada

[11] Univ Hlth Network, Osteoporosis & Womens Hlth Programs, Toronto, ON, Canada

[12] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, Musculoskeletal Quantitat Imaging Res Grp, San Francisco, CA 94143 USA

[13] Univ Calgary, McCaig Inst Bone & Joint Hlth, Dept Radiol, Calgary, AB T2N 4Z6, Canada

来源：

CURRENT OSTEOPOROSIS REPORTS | 2013年 / 11卷 / 02期

关键词：

High-resolution peripheral quantitative computed tomography; Bone strength; Assessment; Bone microarchitecture; VolumetricBMD; Fracture; Age; Therapy; Finite element analysis;

D O I：

10.1007/s11914-013-0140-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bone structure is an integral determinant of bone strength. The availability of high resolution peripheral quantitative computed tomography (HR-pQCT) has made it possible to measure three-dimensional bone microarchitecture and volumetric bone mineral density in vivo, with accuracy previously unachievable and with relatively low-dose radiation. Recent studies using this novel imaging tool have increased our understanding of age-related changes and sex differences in bone microarchitecture, as well as the effect of different pharmacological therapies. One advantage of this novel tool is the use of finite element analysis modelling to non-invasively estimate bone strength and predict fractures using reconstructed three-dimensional images. In this paper, we describe the strengths and limitations of HR-pQCT and review the clinical studies using this tool.

引用

页码：136 / 146

页数：11

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