The hematopoietic stem cell niche-home for friend and foe?

被引：59
作者：
Krause, Daniela S. [1 ,2 ,3 ,4 ]
Scadden, David T. [2 ,3 ,4 ]
Preffer, Frederic I. [1 ]
机构：
[1] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
[4] Harvard Univ, Harvard Stem Cell Inst, Dept Stem Cell & Regenerat Biol, Boston, MA 02114 USA
来源：
CYTOMETRY PART B-CLINICAL CYTOMETRY | 2013年 / 84B卷 / 01期
关键词：
hematopoietic stem cell; bone marrow microenvironment; leukemia stem cell; flow cytometry; ACUTE MYELOID-LEUKEMIA; BONE-MARROW MICROENVIRONMENT; CHRONIC MYELOGENOUS LEUKEMIA; RECEPTOR-ALPHA CHAIN; E-SELECTIN LIGAND; MOUSE MODEL; OSTEOBLASTIC CELLS; INDUCED APOPTOSIS; PROGENITOR CELLS; MURINE MODEL;
D O I：
10.1002/cyto.b.21066
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
The hematopoietic stem cell (HSC) niche is involved in the maintainance and regulation of quiescence, self-renewal and differentiation of hematopoietic stem cells and the fate of their progeny in mammals dealing with the daily stresses to the hematopoietic system. From the discovery that perturbations of the HSC niche can lead to hematopoietic disorders, we have now arrived at the prospect that the HSC niche may play a role in hematological malignancies and that this HSC niche may be a target for therapy. This review attempts to capture the discoveries of the last few years regarding the normal and malignant hematopoietic stem cell niche and possible ways to target this niche. (c) 2012 International Clinical Cytometry Society
引用
收藏
页码：7 / 20
页数：14
相关论文
共 113 条
  • [1] A niche opportunity for stem cell therapeutics
    Adams, G. B.
    Scadden, D. T.
    [J]. GENE THERAPY, 2008, 15 (02) : 96 - 99
  • [2] Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States
    不详
    不详
    不详
    不详
    不详
    [J]. Nature, 2006, 7076 (599-603) : 599 - 603
  • [3] Where New Approaches Can Stem From: Focus on Stem Cell Identification
    Adams, Volker
    Challen, Grant A.
    Zuba-Surma, Ewa
    Ulrich, Henning
    Vereb, Gyoergy
    Tarnok, Attila
    [J]. CYTOMETRY PART A, 2009, 75A (01) : 1 - 3
  • [4] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    Akashi, K
    Traver, D
    Miyamoto, T
    Weissman, IL
    [J]. NATURE, 2000, 404 (6774) : 193 - 197
  • [5] HOXB4-induced expansion of adult hematopoietic stem cells ex vivo
    Antonchuk, J
    Sauvageau, G
    Humphries, RK
    [J]. CELL, 2002, 109 (01) : 39 - 45
  • [6] Osteocytes Embedded Inside Bone Are Essential for G-CSF-Induced Hematopoietic Stem/Progenitor Mobilization
    Asada, Noboru
    Katayama, Yoshio
    Sato, Mari
    Minagawa, Kentaro
    Wakahashi, Kanako
    Kawano, Hiroki
    Kawano, Yuko
    Sada, Akiko
    Ikeda, Kyoji
    Matsui, Toshimitsu
    Tanimoto, Mitsune
    [J]. BLOOD, 2011, 118 (21) : 327 - 328
  • [7] Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance
    Bewry, Nadine N.
    Nair, Rajesh R.
    Emmons, Michael F.
    Boulware, David
    Pinilla-Ibarz, Javier
    Hazlehurst, Lori A.
    [J]. MOLECULAR CANCER THERAPEUTICS, 2008, 7 (10) : 3169 - 3175
  • [8] Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
    Bhardwaj, G
    Murdoch, B
    Wu, D
    Baker, DP
    Williams, KP
    Chadwick, K
    Ling, LE
    Karanu, FN
    Bhatia, M
    [J]. NATURE IMMUNOLOGY, 2001, 2 (02) : 172 - 180
  • [9] ABNORMAL FUNCTION OF THE BONE-MARROW MICROENVIRONMENT IN CHRONIC MYELOGENOUS LEUKEMIA - ROLE OF MALIGNANT STROMAL MACROPHAGES
    BHATIA, R
    MCGLAVE, PB
    DEWALD, GW
    BLAZAR, BR
    VERFAILLIE, CM
    [J]. BLOOD, 1995, 85 (12) : 3636 - 3645
  • [10] Chromosomal aberrations in bone marrow mesenchymal stroma cells from patients with myelodysplastic syndrome and acute myeloblastic leukemia
    Blau, Olga
    Hofmann, Wolf-Karsten
    Baldus, Claudia Dorothea
    Thiel, Gundula
    Serbent, Verena
    Schuemann, Elke
    Thiel, Eckhard
    Blau, Igor Wolfgang
    [J]. EXPERIMENTAL HEMATOLOGY, 2007, 35 (02) : 221 - 229
12345678910