Assessing zinc from a nail clipping using mono-energetic portable X-ray fluorescence

被引:13
作者
Fleming, David E. B. [1 ]
Crook, Samantha L. [1 ]
Evans, Colby T. [1 ]
机构
[1] Mt Allison Univ, Phys Dept, Sackville, NB, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
Mono-energetic X-ray; Portable X-ray fluorescence; Zinc; Nail clippings; Biomarker;
D O I
10.1016/j.apradiso.2018.12.033
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
A mono-energetic X-ray beam from a portable X-ray fluorescence device was used to excite characteristic X-rays from zinc in a series of nail clipping phantoms. Twenty nail clipping phantoms having equal zinc concentrations of similar to 40 mu g/g, but with different physical characteristics, were measured individually for 300 s using a small diameter (similar to 1 mm) X-ray beam. Energy spectra obtained from the measurements were analyzed using PyMca software. Zinc signal size varied widely between the different clippings, with a relative standard deviation of 41% observed in the combined signal from zinc K alpha and K beta characteristic X-rays. Three different normalization approaches were introduced to account for variation in the amounts of sample interrogated by the X-ray beam. All three approaches produced similar results, and successfully reduced the relative standard deviation to between 12% and 13%. A clear trend was still observed, however, between the normalized zinc signal and the thickness of clipping measured. To account for this effect, normalized signals were adjusted to calculate "thickness-corrected" values. The relative standard deviation of these thickness-corrected values was 6.2%. Reproducibility of measurement from individual clippings was excellent, with relative standard deviations on the order of 1%, with or without normalization. Overall, this new method of measuring zinc in nail shows promise for the assessment of zinc status in humans using a portable device, The method is sensitive, rapid, and requires only a single nail clipping.
引用
收藏
页码:170 / 175
页数:6
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