A controlled trial of amantadine hydrochloride and neuroleptics in the treatment of tardive dyskinesia

被引：53

作者：

Angus, S ^{[1
]}

Sugars, J ^{[1
]}

Boltezar, R ^{[1
]}

Koskewich, S ^{[1
]}

Schneider, NM ^{[1
]}

机构：

[1] RAYMOND CARE CTR,PROV MENTAL HLTH ADVISORY BOARD,RAYMOND,AB T0K 2S0,CANADA

来源：

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY | 1997年 / 17卷 / 02期

关键词：

D O I：

10.1097/00004714-199704000-00004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An 18-week, double-blind, crossover study of amantadine and neurolepties in the treatment of tardive dyskinesia (TD) is described. A fixed-dose regimen was used, and objective rating scales for TD, extrapyramidal symptoms, and mental state were employed. The results indicate that amantadine is significantly better than placebo in the management of TD and that there is little risk of exacerbating psychosis. Further investigation of this potentially useful medication is warranted.

引用

页码：88 / 91

页数：4

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