The Ambivalent Role of lncRNA Xist in Carcinogenesis

被引：26
作者：
Chen, Yung-Kang [1 ,2 ]
Yen, Yun [3 ,4 ,5 ,6 ]
机构：
[1] Taipei Med Univ, Sch Med, Taipei, Taiwan
[2] Taipei Vet Gen Hosp, Dept Gen Med, Taipei, Taiwan
[3] Taipei Med Univ, Grad Inst Med Informat, Taipei, Taiwan
[4] Taipei Med Univ, TMU Res Ctr Canc Translat Med, 250 Wuxing St, Taipei 110, Taiwan
[5] Taipei Med Univ, Taipei Municipal Wanfang Hosp, Taipei, Taiwan
[6] Taipei Med Univ, Coll Med Sci & Technol, Program Canc Mol Biol & Drug Discovery, Taipei, Taiwan
来源：
STEM CELL REVIEWS AND REPORTS | 2019年 / 15卷 / 02期
关键词：
Cancer stem cell; Long non-coding RNA; X Chromosome inactivation; XIST non-coding RNA; XACT non-coding RNA; MicroRNAs; Competing endogenous RNA; Exosomes; X-CHROMOSOME INACTIVATION; PLURIPOTENT STEM-CELLS; DOSAGE COMPENSATION; BARR BODY; RNA; CANCER; GENE; EXPRESSION; MAMMALS; BREAST;
D O I：
10.1007/s12015-019-9871-z
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Long non-coding RNA (lncRNA) Xist has emerged as a key modulator in dosage compensation by randomly inactivating one of the X chromosomes in mammals during embryonic development. Dysregulation of X chromosome inactivation (XCI) due to deletion of Xist has been proven to induce hematologic cancer in mice. However, this phenomenon is not consistent in humans as growing evidence suggests Xist can suppress or promote cancer growth in different organs of the human body. In this review, we discuss recent advances of XCI in human embryonic stem cells and provide an explanation for the seemingly contradictory roles of Xist in development of human cancer.
引用
收藏
页码：314 / 323
页数：10
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