Advanced materials and processing for drug delivery: The past and the future

被引：761
|
作者：
Zhang, Ying [1 ]
Chan, Hon Fai [1 ]
Leong, Kam W. [1 ]
机构：
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2013年 / 65卷 / 01期
基金：
美国国家科学基金会;
关键词：
Commercialized drug delivery system; Nanoparticle; Polyplex; Natural polymers; Polymer-drug conjugate; Combinatorial chemistry; Microfluidics; Particle replication in non-wetting template; Step-flash imprint lithography; MONODISPERSED CHITOSAN MICROSPHERES; COMPARING PACLITAXEL POLIGLUMEX; BLOCK-COPOLYMER MICELLES; STOP-FLOW LITHOGRAPHY; IN-VITRO RELEASE; CELL LUNG-CANCER; MICROFLUIDIC DEVICE; CO-DELIVERY; POLYMERIC NANOPARTICLES; POLY(ETHYLENE GLYCOL);
D O I：
10.1016/j.addr.2012.10.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Design and synthesis of efficient drug delivery systems are of vital importance for medicine and healthcare. Materials innovation and nanotechnology have synergistically fueled the advancement of drug delivery. Innovation in material chemistry allows the generation of biodegradable, biocompatible, environment-responsive, and targeted delivery systems. Nanotechnology enables control over size, shape and multi-functionality of particulate drug delivery systems. In this review, we focus on the materials innovation and processing of drug delivery systems and how these advances have shaped the past and may influence the future of drug delivery. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：104 / 120
页数：17
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