Porcine Skin Gelatin Hydrolysate Promotes Longitudinal Bone Growth in Adolescent Rats

被引：14

作者：

Leem, Kang-Hyun ^{[1
]}

Lee, Sena ^{[1
]}

Jang, Aera ^{[2
]}

Kim, Hye Kyung ^{[3
]}

机构：

[1] Semyung Univ, Coll Oriental Med, Jechon, Chungbuk, South Korea

[2] Kangwon Natl Univ, Dept Anim Prod & Food Sci, Chunchon, South Korea

[3] Hanseo Univ, Dept Food & Biotechnol, Seosan 356706, Chungnam, South Korea

来源：

JOURNAL OF MEDICINAL FOOD | 2013年 / 16卷 / 05期

关键词：

BMP-2; collagen hydrolysates; growth plate; IGF-1; longitudinal bone growth; MINERAL DENSITY; PEPTIDES;

D O I：

10.1089/jmf.2012.2461

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Collagen hydrolysates (CHs) are mixtures of peptides obtained by partial hydrolysis of gelatin that are receiving scientific attention as potential oral supplements for the restoration of osteoarticular tissues. The aim of this study was to evaluate the effectiveness of CHs for promoting longitudinal bone growth in growing rats. An in vitro study was carried out in osteoblast-like MG63 cells and the most effective CH on bone formation was selected among 36 various CHs. An in vivo study confirmed the functional effects of a selected CH with molecular weight of <3 kDa on longitudinal bone growth. CHs dose-dependently promoted the longitudinal bone growth and height of the growth plate in adolescent male rats, whereas gelatin failed to affect longitudinal bone growth. Insulin-like growth factor-1 and bone morphogenetic protein-2 in the CH treated group were highly expressed in the growth plate. These results suggest that CHs isolated in this study may provide beneficial effects on bone metabolism of growing animals and humans.

引用

页码：447 / 453

页数：7

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