Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children

被引：0

作者：

Ebadifar, Asghar ^{[1
]}

Ameli, Nazila ^{[4
]}

KhorramKhorshid, Hamid Reza ^{[2
]}

Kamali, Koorosh ^{[3
]}

Zeinabadi, Mehdi Salehi ^{[5
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Dentofacial Deform Res Ctr, Res Inst Dent Sci, Tehran, Iran

[2] Univ Social Welf & Rehabil Sci, Genet Res Ctr, Tehran, Iran

[3] ACECR, Reprod Biotechnol Res Ctr, Avicenna Res Inst, Tehran, Iran

[4] Semnan Univ Med Sci, Sch Dent, Dept Orthodont, Semnan, Iran

[5] Semnan Univ Med Sci, Sch Dent, Dept Pediat, Semnan, Iran

来源：

JOURNAL OF RESEARCH IN MEDICAL SCIENCES | 2016年 / 21卷

关键词：

Folic acid supplementation; methylenetetrahydrofolate reductase gene; orofacial clefts; polymorphism; OROFACIAL CLEFTS; CASE-PARENT; HOMOCYSTEINE; VARIANTS; MUTATION; FOLATE; PLASMA; MTHFR; RISK;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene polymorphisms in Iranian children with oral clefts. Materials and Methods: Forty-seven newborn infants with orofacial cleft and their mothers were selected randomly. Mothers were matched regarding dietary folate intake. The genotyping on venous blood was carried out. Consistency between maternal and child genotypes was analyzed. Results: Genotype consistency was not statistically significant in both C677T and A1298C gene variants (P > 0.05). Conclusion: Maternal folic acid consumption may not have any significant effect on modifying C677T and A1298C polymorphisms in children.

引用

页数：4

共 14 条

[11] Worldwide distribution of a common methylenetetrahydrofolate reductase mutation [J].