Recommendations for the diagnosis and initial evaluation of patients with Waldenstrom Macroglobulinaemia: A Task Force from the 8th International Workshop on Waldenstrom Macroglobulinaemia

被引：56

作者：

Castillo, Jorge J. ^{[1
]}

Garcia-Sanz, Ramon ^{[2
]}

Hatjiharissi, Evdoxia ^{[3
]}

Kyle, Robert A. ^{[4
]}

Leleu, Xavier ^{[5
]}

McMaster, Mary ^{[6
]}

Merlini, Giampaolo ^{[7
]}

Minnema, Monique C. ^{[8
]}

Morra, Enrica ^{[9
]}

Owen, Roger G. ^{[10
]}

Poulain, Stephanie ^{[11
]}

Stone, Marvin J. ^{[12
]}

Tam, Constantine ^{[13
]}

Varettoni, Marzia ^{[14
]}

Dimopoulos, Meletios A. ^{[15
]}

Treon, Steven P. ^{[1
]}

Kastritis, Efstathios ^{[15
]}

机构：

[1] Harvard Med Sch, Dana Farber Canc Inst, Bing Ctr Waldenstrom Macroglobulinemia, 450 Brookline Ave,M221, Boston, MA 02215 USA

[2] Hosp Univ Salamanca, Salamanca, Spain

[3] Theagene Hosp Thessaloniki, Dept Haematol, Thessaloniki, Greece

[4] Mayo Clin, Div Hematol, Rochester, MN USA

[5] CHU Poitiers, La Mil Hosp, Poitiers, France

[6] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[7] Univ Pavia, Fdn IRCCS Policlin San Matteo, Amyloidosis Res & Treatment Ctr, Pavia, Italy

[8] UMC Utrecht Canc Ctr, Dept Haematol, Utrecht, Netherlands

[9] Osped Niguarda Ca Granda, Div Haematol, Milan, Italy

[10] Leeds Teaching Hosp NHS Trust, St Jamess Inst Oncol, Leeds, W Yorkshire, England

[11] Ctr Hosp Valenciennes, Serv Hematol Immunol Cytogenet, Valenciennes, France

[12] Baylor Charles Sammons Canc Ctr, Dept Oncol, Dallas, TX USA

[13] Univ Melbourne, Dept Haematol, Peter MacCallum Canc Ctr, Melbourne, Vic, Australia

[14] Univ Pavia, Fdn IRCCS Policlin San Matteo, Dept Haematol Oncol, Pavia, Italy

[15] Natl & Kapodistrian Univ Athens, Dept Clin Therapeut, Sch Med, Athens, Greece

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2016年 / 175卷 / 01期

关键词：

Waldenstrom macroglobulinaemia; anaemia; neuropathy; hyperviscosity; Bing-Neel syndrome; amyloidosis; CONSENSUS PANEL RECOMMENDATIONS; IGM MONOCLONAL GAMMOPATHY; BING-NEEL SYNDROME; MYD88; L265P; CXCR4; MUTATIONS; LYMPHOPLASMACYTIC LYMPHOMA; GENOMIC LANDSCAPE; LIGHT-CHAIN; SURVIVAL; DISEASE;

D O I：

10.1111/bjh.14196

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The diagnosis of Waldenstrom macroglobulinaemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations that took place to address these issues. We provide recommendations for history-taking and physical examination, laboratory studies, bone marrow aspiration and biopsy analysis and imaging studies. We also provide guidance on the initial evaluation of special situations, such as anaemia, hyperviscosity, neuropathy, Bing-Neel syndrome and amyloidosis. We hope these recommendations serve as a practical guidance to clinicians taking care of patients with a suspected or an established diagnosis of WM.

引用

页码：77 / 86

页数：10

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