Dental stem cells and their promising role in neural regeneration: an update

被引：87
作者：
Martens, W. [1 ]
Bronckaers, A. [1 ]
Politis, C. [1 ,2 ]
Jacobs, R. [3 ]
Lambrichts, I. [1 ]
机构：
[1] Hasselt Univ, Lab Morphol, Biomed Res Inst, B-3590 Diepenbeek, Belgium
[2] Katholieke Univ Leuven, Dept Oral & Maxillofacial Surg, Louvain, Belgium
[3] Katholieke Univ Leuven, Fac Med, Dept Dent Oral Pathol & Maxillofacial Surg, Oral Imaging Ctr, Louvain, Belgium
来源：
CLINICAL ORAL INVESTIGATIONS | 2013年 / 17卷 / 09期
关键词：
Dental stem cells; Neural characteristics; Tooth development; Stem cells; MARROW STROMAL CELLS; INFERIOR ALVEOLAR NERVE; EXFOLIATED DECIDUOUS TEETH; HUMAN BONE-MARROW; NEURONS IN-VITRO; PERIODONTAL-LIGAMENT; SPINAL-CORD; PULP CELLS; ADULT-RAT; APICAL PAPILLA;
D O I：
10.1007/s00784-013-1030-3
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Stem cell-based therapies are considered to be a promising treatment method for several clinical conditions such as Alzheimer's disease, Parkinson's disease, spinal cord injury, and many others. However, the ideal stem cell type for stem cell-based therapy remains to be elucidated. Stem cells are present in a variety of tissues in the embryonic and adult human body. Both embryonic and adult stem cells have their advantages and disadvantages concerning the isolation method, ethical issues, or differentiation potential. The most described adult stem cell population is the mesenchymal stem cells due to their multi-lineage (trans)differentiation potential, high proliferative capacity, and promising therapeutic values. Recently, five different cell populations with mesenchymal stem cell characteristics were identified in dental tissues: dental pulp stem cells, stem cells from human exfoliated deciduous teeth, periodontal ligament stem cells, dental follicle precursor cells, and stem cells from apical papilla. Each dental stem cell population possesses specific characteristics and advantages which will be summarized in this review. Furthermore, the neural characteristics of dental pulp stem cells and their potential role in (peripheral) neural regeneration will be discussed.
引用
收藏
页码：1969 / 1983
页数：15
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